Author(s):
Abhishek Kumar, Pankaj Kumar, Fathima Nihana
Email(s):
pankajpgr@gmail.com
DOI:
10.5958/0974-360X.2017.00390.0 
Address:
Abhishek Kumar, Pankaj Kumar*, Fathima Nihana
Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte-575018, Mangalore, Karnataka.
*Corresponding Author
Published In:
Volume - 10,
Issue - 7,
Year - 2017
ABSTRACT:
A series of novel substituted 3-(2,4-dimethyl-1H-pyrrol-3-yl)-5-phenyl-4,5-dihydroisoxazole (AFI1-AFI6) have been synthesized upon reaction with 3-(2,4-dimethyl-1H-pyrrol-3-yl)-1-phenyl-prop-2-en-1-one using hydroxylamine hydrochloride as cyclising agent in alcohol medium. 3-(2,4-dimethyl-1H-pyrrol-3-yl)-1-phenyl-prop-2-en-1-one were synthesized by condensing 3-acetyl-2,4-dimethyl pyrrole with different substituted benzaldehyde in presence of ethanolic 20% KOH. The structures of the final synthesized compounds were characterized by IR and 1H NMR spectra. The final synthesized compounds were screened for their in vitro antibacterial activity by cup plate method.
Cite this article:
Abhishek Kumar, Pankaj Kumar, Fathima Nihana. Synthesis and Antimicrobial Evaluation of Some New Isoxazoline Incorporated Pyrrole Derivatives. Research J. Pharm. and Tech. 2017; 10(7): 2210-2212. doi: 10.5958/0974-360X.2017.00390.0
Cite(Electronic):
Abhishek Kumar, Pankaj Kumar, Fathima Nihana. Synthesis and Antimicrobial Evaluation of Some New Isoxazoline Incorporated Pyrrole Derivatives. Research J. Pharm. and Tech. 2017; 10(7): 2210-2212. doi: 10.5958/0974-360X.2017.00390.0 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2017-10-7-41