Background: Breast cancer is the most common form of cancer among women worldwide, with the increase incidence and its associated morbidity, mortality, and enormous treatment costs, there is a great interest in strategies of prevention and detection of early prognostic factors. Serum CRP levels could be a marker of increased risk for breast cancer.
Aim of the study: Evaluation of estrogen-receptor ER, progesterone-receptor PR and human epidermal growth factor receptor 2 Her-2 expression in 60 female-patients of breast cancer in Jableh-Syria, and studying their relation with serum CRP levels and other prognostic factors.
Patients and methods: 60 female- patients of breast cancer aged between 32 to 77 years old, admitted in National hospital of Jableh (Jableh- Syria) were selected from December 2015 until December 2016. Blood samples were collected for CRP levels on admission and measured by immunoturbidimetric determination, levels >5mg/l were considered positive. ER- receptor, PR- receptor and Her-2 expression were assessed.
Results: Triple positive receptors TP was the major subgroup of patients (n=21, 35%, p. value= 0.049). Relation between ER-receptor and PR-receptor expression was strongly significant (n= 37, 90.24%, p. value < 0.0001), Patients positive for Her-2 receptor expression were =46 years (n=27, 84.38%, p, value=0.039). Patients positive for serum CRP levels were positive for ER-receptor expression (n=26, 63.41%, p. value=0.021). Mean of CRP levels were increased with stage and difference was not significant. Patients with positive lymph nodes count >4 had higher grade (n=28, 75.78%, p. value= 0.009) and stage (n=24, 64.86%, p. value= 0.002), and were positive for PR-receptor expression (n=31, 83.71%, p. value= 0.008).
Conclusion: 90% of patients have same histological diagnosis (invasive ductal carcinoma IDC), but present high variety of ER-receptor, PR-receptor and Her-2 receptor expression as heterogenic subtypes breast cancer, which propose different strategies of prevention and protocols of therapy. CRP levels could be a biomarker for invasive and progression of cancer according to stage and pN staging. Serum CRP levels could predict patients positive for ER-receptor, those who will benefit of modulation of ER-receptor expression as a routine strategy of prevention.
Cite this article:
Remal Abdulaziz Asaad. Hormone Receptor Status and its Relation to C-Reactive Protein and other Prognostic factors in Breast Cancer in Jableh- Syria. Research J. Pharm. and Tech. 2017; 10(9): 3003-3010. doi: 10.5958/0974-360X.2017.00532.7
Remal Abdulaziz Asaad. Hormone Receptor Status and its Relation to C-Reactive Protein and other Prognostic factors in Breast Cancer in Jableh- Syria. Research J. Pharm. and Tech. 2017; 10(9): 3003-3010. doi: 10.5958/0974-360X.2017.00532.7 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2017-10-9-32