ABSTRACT:
The synthesis of new heterocyclic compounds has always drawn the attention of medicinal chemist over the years mainly because they possess diverse biological properties. The literature survey on 1,2,4-triazoles revealed that they are endowed with wide variety of biological activities. During the present investigation a series of new 1,2,4-triazole derivatives N-(3-(2-(3-hydrazinyl-3-oxoalkanoyl)hydrazinyl)-5(phenoxymethyl)-4H-1,2,4-triazol-4-yl)isonicotinamide(6a-6e) were synthesized by reacting with N-(5-mercapto-3-(phenoxymethyl)-4H-1,2,4-triazol-4-yl)isonicotinamide (5) and aliphatic dicarboxylic acid hydrazides (a-e). The structures of the newly synthesized compounds were established by FT-IR, 1H-NMR and MASS spectral analysis. All the compounds synthesised 6a to 6e were evaluated for anti-tubercular activity against Mycobacterium tuberculosis H37Rv using MABA method. The compound 6a (n=0) was found to be the most potent anti-tubercular agent. Few of the other compounds in the series also showed significant anti-tubercular properties.