Author(s): Abhishek Kumar, Pankaj Kumar, Jean Sandra Pinto, Bhashini, Akshata

Email(s): pankajpgr@gmail.com

DOI: 0.5958/0974-360X.2018.00900.9   

Address: Abhishek Kumar, Pankaj Kumar*, Jean Sandra Pinto, Bhashini, Akshata
Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences,
NITTE (Deemed to be University) , Paneer, Deralakatte-575018, Mangalore, Karnataka.
*Corresponding Author

Published In:   Volume - 11,      Issue - 11,     Year - 2018


ABSTRACT:
A series of new substituted coumarinyl schiff base (AJS1-AJS6) have been synthesized by condensing substituted 3-acetyl coumarin and substituted aniline in alcohol medium. The intermediate 3-acetyl coumarin were synthesized by Knoevenagel reaction between substituted salicylaldehyde and ethylacetoacetate in presence of piperidine as catalyst. The structures of the final synthesized compounds were characterized by IR, mass and 1H NMR spectra. The synthesized compounds were screened for their antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa by tube dilution method. Most of the compounds exhibited promising antibacterial activity compared to the standard drug ciprofloxacin.


Cite this article:
Abhishek Kumar, Pankaj Kumar, Jean Sandra Pinto, Bhashini, Akshata. Synthesis and Antimicrobial Evaluation of Some new Coumarinyl Schiff Base Derivatives. Research J. Pharm. and Tech 2018; 11(11): 4946-4948. doi: 0.5958/0974-360X.2018.00900.9

Cite(Electronic):
Abhishek Kumar, Pankaj Kumar, Jean Sandra Pinto, Bhashini, Akshata. Synthesis and Antimicrobial Evaluation of Some new Coumarinyl Schiff Base Derivatives. Research J. Pharm. and Tech 2018; 11(11): 4946-4948. doi: 0.5958/0974-360X.2018.00900.9   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2018-11-11-32


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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