ABSTRACT:
Newly developed ion selective electrode has been developed for determination of Clopidogrelbisulphate(CLP) in pure form and pharmaceutical preparations. The selective electrode was constructed from Clopidogrel with pairing agent Nesslerreagentin presence of di-n-butyl phthalate (DBP) as the plasticizing solvent mediator. The electrode displayed a Nernstian response with a mean calibration graphs slopeof 28.37 mv.decade-1,over linear concentration range 10-2-10-5M of the drug, with detection limits 0.063 µMand quantification limits 0.191 µM. The electrode was effective at pH range between 1-3. The influence of possible interfering species such as inorganic cations and pharmacologically related compounds was studied. The electrode showed a fast response of (18±2 sec) for a period of 11 days,without significant change in electrode parameters. The method is precise as shown by mean recoveries range of (97.9-102.9 %)with a mean relative standard deviation less than 2.80. The results were compared to those obtained by a reference method. The proposed electrode was used for the determination of CLP in pure form and pharmaceutical formulation.