Author(s):
Ajazuddin, Tripti Banjare, Amit Alexander, Palak Agrawal, Akansha Bhandarkar, Aditi Bhatt, Swapnil Gupta, Hemlata Sahu, Shradha Devi Diwedi, Pankaj Sahu, Siddharth Kumar Sahu, Pooja Yadav, Kailash Sahu, Deeksha Dewangan, Hemlata Thapa, Deepika, Sonam Soni, Mukesh Sharma, D. K. Tripathi
Email(s):
write2ajaz@gmail.com , ajazuddin@rungta.ac.in
DOI:
10.5958/0974-360X.2018.00378.5 
Address:
Dr. Ajazuddin1*, Tripti Banjare2, Amit Alexander2, Palak Agrawal2, Akansha Bhandarkar2, Aditi Bhatt2, Swapnil Gupta2, Hemlata Sahu2, Shradha Devi Diwedi2, Pankaj Sahu2, Siddharth Kumar Sahu2, Pooja Yadav2, Kailash Sahu2, Deeksha Dewangan2, Hemlata Thapa2, Deepika2, Sonam Soni2, Mukesh Sharma2, D. K. Tripathi2,
1Professor, Department of Pharmaceutics, Rungta College of Pharmaceutical Sciences and Research Kohka, Kurud Road, Bhilai, Chhattisgarh, India, 490024
2Rungta College of Pharmaceutical Sciences and Research, Kohka-kurud road, Bhilai, Chhattisgarh, 4900024
*Corresponding Author
Published In:
Volume - 11,
Issue - 5,
Year - 2018
ABSTRACT:
Targeting of drug to the colon oral route the drug release is controlled by the gastrointestinal pH, transit times and intestinal flora. Metronidazole is only used antibiotics, which can be used, in colonic disease. Matrix formulations containing various proportions of Xanthan gum and HPMC E5LV were prepared by wet granulation technique using 10% starch paste. Six Matrix tablet formulation (1 to 6) of Metronidazole were prepared different mixture of Xanthan gum and HPMC-E5LV. All the formulations were evaluated for in-process quality control tests. The in-vitro drug release study first in 0.1N HCl followed by in pH 7.4 phosphate buffer, the formulation F3 show good drug release in control manner. Hence, synthetic polymer such as HPMCE5LV is most cheap and suitable for colonic drug delivery.
Cite this article:
Ajazuddin, Tripti Banjare, Amit Alexander, Palak Agrawal, Akansha Bhandarkar, Aditi Bhatt, Swapnil Gupta, Hemlata Sahu, Shradha Devi Diwedi, Pankaj Sahu, Siddharth Kumar Sahu, Pooja Yadav, Kailash Sahu, Deeksha Dewangan, Hemlata Thapa, Deepika, Sonam Soni, Mukesh Sharma, D. K. Tripathi. Formulation and Evaluation of Colon Specific Matrix Tablet of Metronidazole. Research J. Pharm. and Tech 2018; 11(5):2040-2044. doi: 10.5958/0974-360X.2018.00378.5
Cite(Electronic):
Ajazuddin, Tripti Banjare, Amit Alexander, Palak Agrawal, Akansha Bhandarkar, Aditi Bhatt, Swapnil Gupta, Hemlata Sahu, Shradha Devi Diwedi, Pankaj Sahu, Siddharth Kumar Sahu, Pooja Yadav, Kailash Sahu, Deeksha Dewangan, Hemlata Thapa, Deepika, Sonam Soni, Mukesh Sharma, D. K. Tripathi. Formulation and Evaluation of Colon Specific Matrix Tablet of Metronidazole. Research J. Pharm. and Tech 2018; 11(5):2040-2044. doi: 10.5958/0974-360X.2018.00378.5 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2018-11-5-62