ABSTRACT:
Background/Objectives: The aim of the study was to find outthe effects that SM-215 leads to the improvement of androgenetic alopecia. Methods/Statistical analysis: Male C3H/HeNSic (10 weeks of age) mice were divided into the control group, aging-elicited group (AE group), SM-215 treatment group (ST group). The AE and ST groups were shaved, followed by application of SM-215 at 30 mg/kg/day for 5 weeks in the ST group. Changes in external morphology were observed and immunohistochemical staining and TUNEL assays were conducted .The significance of the results was verified by one-way ANOVA. Findings: A large number of dorsal hairs were grossly observed following treatment with SM-215, significantly reducing SREBP-1 and SCAP positivity in hair follicles, and p-JNK, p-IkB, SPTLC positive reaction, apoptosis in TUNEL assay. SM-215 also significantly increased CD34, SHH and IGF-1 positive reaction. Improvements/Applications: As a result, SM-215 can be considered to be effective in relieving hair follicle damage caused by androgens, decreasing scalp inflammation, activating dormant hair follicles, and promoting epithelial cell growth around hair follicles, thereby alleviating androgenetic alopecia.