Author(s):
Ruslan Glushakov, Konstantin Sulin, Alexander Semenov, Bogdan Kotiv, NataliaTapilskaya
Email(s):
rglushakov@yahoo.com
DOI:
10.5958/0974-360X.2018.00430.4 
Address:
Ruslan Glushakov1*, Konstantin Sulin1, Alexander Semenov2,3, Bogdan Kotiv1, NataliaTapilskaya4,5
1Military Medical Academy N.A.S.M. Kirov, Ministry of Defense of Russian Federation, St. Petersburg.
2Research Institute of Oncology named after N.N. Petrov,
Ministry of Healthcare of Russian Federation, St. Petersburg.
3Russian Research Center of Radiology and Surgical Technologies,
Ministry of Healthcare of Russian Federation, St. Petersburg.
4St. Petersburg State Pediatric Medical University, Ministry of Healthcare of Russian Federation, St. Petersburg.
5Scientific Center for Obstetrics, Gynecology and Perinatology named after academician V.I. Kulakov,
Ministry of Healthcare of Russian Federation, Moscow
*Corresponding Author
Published In:
Volume - 11,
Issue - 6,
Year - 2018
ABSTRACT:
Our study examined the effect of induced hypo- and hyperthyroidism on ovarian cancer (OC). The intraperitonealxenograft model of OCperformed the standard technique. Using propylthiouracil(2,0 mg per 100 g of animal weight once a day) and L-thyroxine(200 µg per 100 g of animal weight once a day)we found that altered thyroid status significantly influenced the ovary tumor xenograftsdevelopment. The median survival life expectancy was 9,6 and 17,6 daysin the euthyroidcontrol group and the hypothyroidgroup, respectively (p?= 0.02). Induced hypothyroidismleads to thelifetime increase of rats with intraperitonealxenograftof OC by 83.3%. It was shown that hyporthyroidism was associated with the aggressiveness decrease of OC. Ourevidence confirms previous clinical and epidemiologicaldata.Thyroid status can be anindepending prognostic factor for patients with OC, as well as induced hypotyroidism opens new opportunities for the palliative treatment of OC.
Cite this article:
Ruslan Glushakov, Konstantin Sulin, Alexander Semenov, Bogdan Kotiv, NataliaTapilskaya. The Effect on the Altered Thyroid Status for Ovarian Tumor Xenografts in Rats. Research J. Pharm. and Tech 2018; 11(6): 2317-2322. doi: 10.5958/0974-360X.2018.00430.4
Cite(Electronic):
Ruslan Glushakov, Konstantin Sulin, Alexander Semenov, Bogdan Kotiv, NataliaTapilskaya. The Effect on the Altered Thyroid Status for Ovarian Tumor Xenografts in Rats. Research J. Pharm. and Tech 2018; 11(6): 2317-2322. doi: 10.5958/0974-360X.2018.00430.4 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2018-11-6-31