ABSTRACT:
Their study was led to explore the impact of finasteride (Prostacare) on testicular capacity in Rattus Norvegicus. Forty five matured male rats with body weight of (200-300g) and (8) to (10) weeks of age were divided into (3) groups (15 rats/group). The first group was given orally with distilled water as acontrol and the others (second and third) were given orallywith two concentrations of finasteride (5mg /kg.b.w and 10mg /kg.b.w) daily for a period of (eight weeks). After the finish of the experiment ,rats was scarifiedfor the purpose of histological study and measurement of organs weights in the laboratory. The results showed a significant (p<0.05) decrease in the body, testis, epididymis and prostate gland weightsin compared with the control. Also the results of histological examination of testis and epididymis showed a significant (p<0.05) reduce in the seminiferous tubules diameters and reduction in number of the leydig’s cells, while there was a significant (p<0.05) rise in the interstitial spacebetween tubules compared to the control group.The results was showed necrosisin the seminiferous tubules of the testis.