Author(s): Pankaj Kumar, Abhishek Kumar, Prashant Nayak, Jean Sandra pinto, Brynish D’Souza

Email(s): abhi12bunty@gmail.com

DOI: 10.5958/0974-360X.2018.00453.5   

Address: Pankaj Kumar1, Abhishek Kumar1*, Prashant Nayak2, Jean Sandra pinto3, Brynish D’Souza3
1Department of Pharmaceutical Chemistry, Nitte University, Paneer, Deralakatte-575018, Mangalore, Karnataka.
2Department of Pharmaceutics, Nitte University, Paneer, Deralakatte-575018, Mangalore, Karnataka.
3NGSM Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte-575018, Mangalore, Karnataka.
*Corresponding Author

Published In:   Volume - 11,      Issue - 6,     Year - 2018


ABSTRACT:
The synthesis and antimicrobial evaluation of some novel pyrazoline incorporated pyrrole derivatives has been presented. In this particular presentation novel substituted pyrazoline incorporated pyrrole derivatives (PKS3a-PKS3e) were synthesized by simple condensation reaction between different substituted aldehydes and 3 acetyl -2,4-dimethyl pyrrole in presence of a strong ethanolic base to yield the pyrrolechalcones. The final synthesized pyrazolincompounds is prepared by the cyclization of pyrrolylchalcones with hydrazine hydratein presence of ethanol. The structures of the final synthesized compounds were characterized by IR, Mass and 1H NMR spectra.The synthesized compounds were screened for their antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosaby cup plate method. Most of the compounds exhibited promising antibacterial activity.


Cite this article:
Pankaj Kumar, Abhishek Kumar, Prashant Nayak, Jean Sandra pinto, Brynish D’Souza. Synthesis and Antimicrobial Evaluation of some Novel Pyrazoline Incorporated Pyrrole Derivatives. Research J. Pharm. and Tech 2018; 11(6): 2460-2462. doi: 10.5958/0974-360X.2018.00453.5

Cite(Electronic):
Pankaj Kumar, Abhishek Kumar, Prashant Nayak, Jean Sandra pinto, Brynish D’Souza. Synthesis and Antimicrobial Evaluation of some Novel Pyrazoline Incorporated Pyrrole Derivatives. Research J. Pharm. and Tech 2018; 11(6): 2460-2462. doi: 10.5958/0974-360X.2018.00453.5   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2018-11-6-54


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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