ABSTRACT:
Indanone acetic acid is a non-heterocyclic fused ring of benzene attached to cyclopentananone moiety with acetic acid side chain at 1-position. A simple and efficient method has been developed for the synthesis by condensation of indanone acetic acid with various substituents like aniline, o-toludine, 2-chloroaniline, 3-chloroaniline, o-anisidine, and p-fluoroaniline to obtain substituted indanone acetic acid (5a-f) derivatives. The newly synthesized compounds were structurally con?rmed by analytical and spectral data and evaluated for their antimicrobial activities. Antimicrobial activity of synthesized compounds were screened by using gram positive Staphylococcus aureus, Bacillus subtilis and gram negative Escherichia coli and Salmonella typhi microbial cultures and fungal strains Candida albicans and Aspergillus niger with reference to standard drug. The results showed that para-fluorophenyl substituted indanone acetic acid (5f) derivative exhibited marked potency as antimicrobial agents and ortho-methoxyphenyl (5d) derivative exhibited better antifungal activity.