ABSTRACT:
Carcinogenesis is a process in which normal cell of the body is altered into cancer cell. It is characterized by genetic variation that effects key cellular pathways involved in progression and development. In cancer, cells tend to proliferate in an enormously and untimely way due to change in its metabolism and behavior. Breast cancer is most frequent and prime cause of women cancer mortality worldwide. Breast cancer is an outcome from mutations in a gene which are either present in the germ line of the infected individual or which are acquired in the breast cells. The proportion of breast cancers triggered by germline mutations. Although one- fifth women affected of breast cancer found to have one relative with breast cancer. However, inheritance of germline mutations is estimated in breast cases is less (5%-10%). Thus, it is apparent that an understanding genetics of the breast cancer has turn into more relevant in the monitoring of pathogenesis. This review has been focused on presence of various intrinsic factors in breast cancer and how it is significance in the present scenario of advance therapeutics treatment.