Author(s):
P. P. Chinchole, S. B. Wankhede
Email(s):
pavanchinchole@gmail.com , direct2sagar@gmail.com
DOI:
10.5958/0974-360X.2019.00862.X 
Address:
P. P. Chinchole1*, S. B. Wankhede2
1Padmashree Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune. India – 411018.
2JSPM’s Charak College of Pharmacy and Research, Gate No. 720/1&2, Wagholi, Pune-Nagar Road, Pune. India – 412207
*Corresponding Author
Published In:
Volume - 12,
Issue - 10,
Year - 2019
ABSTRACT:
In the present study a series of 3-substituted isatin derivatives were screened in silico by docking method for anti-inflammatory activities. The screened compound shows optimum binding energy in the range of -7.72 to -10.64kcal/mol. The compound P40 have shown the significant binding energy of -10.64kcal/mol. Most of the compounds shown significant anti-inflammatory activity compared with the Indomethacin as standard drugs. Furthermore bioactive analogue showing maximum in-silico activity were synthesized and confirmed by physical and spectral analysis and subjected to in vitro study of anti-inflammatory activity. Results are expressed by using one way ANOVA with Dunnet’s t test. Compounds P26, P28, P30, P34, P37 and P40 were found to have significant analgesic and anti-inflammatory activity.
Cite this article:
P. P. Chinchole, S. B. Wankhede. Comparative In Silico drug likeness and In vitro study of some Schiff’s bases as potent COX-II Inhibitors. Research J. Pharm. and Tech. 2019; 12(10): 4973-4980. doi: 10.5958/0974-360X.2019.00862.X
Cite(Electronic):
P. P. Chinchole, S. B. Wankhede. Comparative In Silico drug likeness and In vitro study of some Schiff’s bases as potent COX-II Inhibitors. Research J. Pharm. and Tech. 2019; 12(10): 4973-4980. doi: 10.5958/0974-360X.2019.00862.X Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2019-12-10-72