Author(s):
Subrahmanyam Lanka, Vaikuntarao Lakinani, Sagar Rao Kanaparthi, Siva Rama Rao Kakani
Email(s):
tvkpnr1985@gmail.com
DOI:
10.5958/0974-360X.2019.00941.7 
Address:
Subrahmanyam Lanka1*, Vaikuntarao Lakinani1, Sagar Rao Kanaparthi1, Siva Rama Rao Kakani2
1Department of Chemistry, GITAM Institute of Science, GITAM University, Visakhapatnam, India
2North East Frontier Technical University, Arunachal Pradesh
*Corresponding Author
Published In:
Volume - 12,
Issue - 11,
Year - 2019
ABSTRACT:
Prostate cancer is a major cause of male death worldwide and the identification of new efficient treatments is constantly needed. Different non-steroidal androgen receptor antagonists are approved also in the case of castration-resistant cancer forms. Using a rational approach and molecular modelling studies to modify the structure of antiandrogen drug bicalutamide, a new series of phenylsulfonyl-benzamide derivatives was designed and synthesised. Their antiproliferative activities were evaluated in four different human prostate cancer cell lines and several new compounds showed significantly improved IC50 values in the low µM range. The cytotoxicity profile was also evaluated for the novel structures in the HEK293 cell line.
Cite this article:
Subrahmanyam Lanka, Vaikuntarao Lakinani, Sagar Rao Kanaparthi, Siva Rama Rao Kakani. Design and Synthesis of Novel Molecular Scaffolds of Bicaultamide derivatives for the treatment of Prostate Cell Cancer. Research J. Pharm. and Tech. 2019; 12(11): 5427-5432. doi: 10.5958/0974-360X.2019.00941.7
Cite(Electronic):
Subrahmanyam Lanka, Vaikuntarao Lakinani, Sagar Rao Kanaparthi, Siva Rama Rao Kakani. Design and Synthesis of Novel Molecular Scaffolds of Bicaultamide derivatives for the treatment of Prostate Cell Cancer. Research J. Pharm. and Tech. 2019; 12(11): 5427-5432. doi: 10.5958/0974-360X.2019.00941.7 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2019-12-11-53