ABSTRACT:
To evaluate the role of grape seed extract in mitigation the effects of thyroid disorders on some blood parameters, Sixty healthy male white rats were used in the current study, divided in six groups (n=10) each group treated as flow: control group (C) given distil water for 45 days. First treatment (T1) given oral dose of 30 mg/kg carbimazole for 45 days as control positive, Second treatment (T2) given oral dose of 20mg/kg L-thyroxin for 45 days as control positive, Third treatment (T3) given oral dose of 150mg/kg GSE for 45 days as control negative, Fourth treatment (T4) given oral dose of 30mg/kg carbimazole for 15 days to induced hypothyroidism then given 30mg/kg carbimazole synchronously with 150mg/kg GSE for 30 days. Fifth treatment (T5) given oral dose of 20mg/kg L-thyroxin for 15 days to induced hyperthyroidism then given 20mg/kg L-thyroxin synchronously with 150mg/kg GSE for 30 days. The results (table1) showed that there was no significant decrease (P>0.05) in RBC result in T1 but was there significant increase (P<0.05) in T2 treatment compared with control, while results showed significant decrease (P<0.05) in each of PCV, Hb and ESR in booth T1 and T2 treatments compared with control, Total count of WBC results (table 2) showed significant increase (P<0.05) in T1 and significant decrease (P<0.05) in T2 compared with control, This was accompanied by significant differences in MO, ECIDO, LY and NE when comparing the results of these parameters in T1 and T2 treatments with control. As for T3 treatment which in turn were closely related without no significant difference with control group. Fourth group results experienced improvement in RBCs and Hb closely to control whereas PCV parameter was relative to control and also not significantly different from its rate in the first group, ESR results in this group did not differ significantly compared with control group while WBC results decreased significantly (P<0.05) compared with control and T1. The fifth group result they were close to normal range of all parameters in control group as well as compared with third treatment, in contrast results of this fifth treatment were differ significantly towards improvement in these parameters compared with second group which treated with L-thyroxin alone. According to these results we can conclude that grape seeds extract have important role in mitigation thyroid disorders on blood parameters.