Author(s):
S. Dhakshanamoorthy, N. Sri Gayathrai Devi, M. Murali Krishnan, M. N. Arumugham
Email(s):
aru_mugham@yahoo.com
DOI:
10.5958/0974-360X.2019.00083.0 
Address:
S. Dhakshanamoorthy1, N. Sri Gayathrai Devi1, M. Murali Krishnan2, M. N. Arumugham1*
1Department of Chemistry, Thiruvalluvar University, Vellore – 632115. Tamilnadu, India
2Department of Chemistry, Bannari Amman Institute of Technology, Sathyamangalam - 638401. Tamilnadu, India
*Corresponding Author
Published In:
Volume - 12,
Issue - 2,
Year - 2019
ABSTRACT:
In this paper cobalt complex of type [Co(Bipy)2(8HQ)](ClO4)2 [Bipy = 2,2’-bipyridyl, HQ = 8-Hydroxy Quinoline) has been synthesized and characterized by elemental analyses, NMR, UV-visible, infrared spectral studies. DNA binding properties of this metal complex was investigated using absorption spectroscopy, fluorescence spectroscopy, viscosity measurements and cyclic voltammetry. The experimental results indicate that the complex bind to DNA through an intercalative mode. The complex tested for biological activity and it has good antibacterial and antifungal activity on comparing with standard drugs.
Cite this article:
S. Dhakshanamoorthy, N. Sri Gayathrai Devi, M. Murali Krishnan, M. N. Arumugham. DNA Binding and Antimicrobial Activity of cobalt (III) complex containing 2,2’ bipyridyl and 8-hydroxy quinoline as ligands. Research J. Pharm. and Tech 2019; 12(2):472-476. doi: 10.5958/0974-360X.2019.00083.0
Cite(Electronic):
S. Dhakshanamoorthy, N. Sri Gayathrai Devi, M. Murali Krishnan, M. N. Arumugham. DNA Binding and Antimicrobial Activity of cobalt (III) complex containing 2,2’ bipyridyl and 8-hydroxy quinoline as ligands. Research J. Pharm. and Tech 2019; 12(2):472-476. doi: 10.5958/0974-360X.2019.00083.0 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2019-12-2-2