Author(s):
Senthil Rajan, Satheesh Babu, Nurliana Binti Ali, Venkata Srikanth Meka, B. Arul Kumar
Email(s):
arulnkl018@gmail.com
DOI:
10.5958/0974-360X.2019.00113.6 
Address:
Senthil Rajan1,2, Satheesh Babu3, Nurliana Binti Ali2, Venkata Srikanth Meka2, B. Arul Kumar1*
1Department of Pharmaceutics, Swamy Vivekanandha College of Pharmacy, Tiruchengode
2School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia
3Faculty of Pharmacy, Lincoln University College, Petaling Jaya, Malaysia
*Corresponding Author
Published In:
Volume - 12,
Issue - 2,
Year - 2019
ABSTRACT:
The aim and objective of the research work is to find out the suitability of starch extracted from Chickpea (Cicer arietinum) as super disintegrant in Losartan Potassium Fast Disintegrating Tablet. The study includes preformulation characterization of starch extracted from Chickpea (Cicer arietinum) and its compatibility with drug Losartan potassium and other excipients of the formulation. Compatibility of formulation ingredients were observed by using Fourier transform infrared spectroscopy (FTIR) and Differential scanning calorimetry (DSC) studies. The disintegrant activity of Chickpea (Cicer arietinum) is compared parallely with the disintegrant crospovidone. Losartan potassium fast disintegrating tablet (LCP01, LCP02 and LCP03) were formulated with crospovidone and Losartan potassium fast disintegrating tablet (LCS01, LCS02, LCS03. LCS04, LCS05, LCS06) were formulated with chickpea starch as disintegrant. Physicochemical characterisation of formulated Losartan potassium fast disintegrating tablets was performed to find out the better formulation.
Cite this article:
Senthil Rajan, Satheesh Babu, Nurliana Binti Ali, Venkata Srikanth Meka, B. Arul Kumar. Pharmaceutical Excipient Behaviour of Chickpea (Cicer arietinum) Starch in Losartan Potassium Fast Disintegrating Tablet. Research J. Pharm. and Tech 2019; 12(2):637-643. doi: 10.5958/0974-360X.2019.00113.6
Cite(Electronic):
Senthil Rajan, Satheesh Babu, Nurliana Binti Ali, Venkata Srikanth Meka, B. Arul Kumar. Pharmaceutical Excipient Behaviour of Chickpea (Cicer arietinum) Starch in Losartan Potassium Fast Disintegrating Tablet. Research J. Pharm. and Tech 2019; 12(2):637-643. doi: 10.5958/0974-360X.2019.00113.6 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2019-12-2-32