ABSTRACT:
Psoriasis was initially considered one of the disorders of keratinocytes. At present it has been classified as one of the autoimmune diseases mediated by T cells, The aim of this study was to identify the effect of biologic therapy on the factors responsible for oxidative stress and lipid oxidation and compare it with TNF-a in a sample of patients with psoriasis and treated with Etanercept. The study sample consisted of 137 people, 48 patients treated with Etanercept, 50 people representing the healthy group (control), 20 patients treated with MTX and 19 treated with topical treatment. The results of the present study showed a significant decrease in the level of motor TNF-a in serum group of patients with psoriasis and treated with biological therapy (33.66 ± 3.41)There was also a non significant increase in the effectiveness of the CAT enzyme between the control group and the biological treatment group as it was effective in the serum of patients treated with biological treatment (6.42 ± 0.44). The results of the measurement of the level of Glutathion enzyme in the serum there is a significant increase between the treatment groups and control group, Significant decrease in MDA concentration between the treatment groups compared to the control group. We conclude that the height of both GSH concentration, CAT efficacy and low MDA concentration indicates a decrease in lipid oxidation process, reduced oxidative stress and reduced disease progression and severity after treatment with etanercept psoriasis.