ABSTRACT:
The main aim of this work was to formulate the extract obtained from Zingiber officinale (Ginger) in to an emulgel and study its microbial activity and different characterisation. methanolic extract of dried rhizome of Zingiber officinale were subjected to many tests to identify the required active constituent. Emulgel formulations were prepared using different concentration of gelling agents i.e sodium CMC. The influence of the different concentration of the gelling agent on the drug release from the prepared emulgel was investigated. The prepared emulgel were evaluated for their physical appearance, pH, Spreadability, in-vitro drug release, antimicrobial activity and stability. From the results it was found that the formulation F3 with 1.5g of Sodium CMC shows better drug release (98.22% at 8 h) and higher antimicrobial activity compared to other formulations. The present work focuses on the potential of extracts for topical antibacterial purposes.