ABSTRACT:
Ailanthus excelsa, Roxb (Family-Simaroubaceae) commonly known as “Mahaneem” is a large deciduous tree with rough and light grey stem bark. It has a large panel of indications to evaluate its stem bark as it contains variety of important phytoconstituents which are used in treating diarrhoea, dysentery, cholera, astringent, febrifuge, anthelmintic and liver tonic. Background: The stem bark of the Ailanthus excelsa, Roxb was investigated for hyperlipidemia related disorders which is one of the major risk factor of coronary heart disease and atherosclerosis Hypothesis / Purpose: The purpose of present investigation is the reduction of elevated lipid profiles through various prepared plant extracts in triton WR 1339 induced hyperlipidemic model. Study Design: In the present investigations, stem bark was collected, authenticated, extracted with solvent and in vivo studies in correlation with triton injected experimental animals were carried out in decreasing the elevated lipid profiles. Methods: The study pertains the hypolipidemic activity of ethanolic extract and its fractions of stem bark of Ailanthus excelsa, Roxb on triton WR 1339 induced hyperlipidemic model. Results: The results obtained are significant with fractionated part of ethonolic extract of Ailanthus excelsa Roxb (200 + 200 mg/kg) in lowering total cholesterol, triglycerides, High density lipoprotein, low density lipoprotein and Very low density lipoprotein. Conclusion: The observation enables to evaluate the biological and molecular approaches to restrain the adverse effects of cardiovascular disorder particularly complications related to lipidemia.