ABSTRACT:
Magnetically modulated system is a promising targeted drug delivery approach which uses an external magnetic field to control the delivery of drug at a specific site avoiding other cellular toxicities. These magnetic particles have the ability to accumulate at a desired site by the guidance of an external magnetic field. So, magnetically modulated materials can be used for diagnostic and targeted drug delivery approaches. This review describes about various applications of magnetically modulated system. Magnetic nanoparticles can be used in a wide variety of applications ranging from contrast agents for magnetic resonance imaging to the destruction of cancer cells via hyperthermia treatment and targeted therapy. Superparamagnetic nanoparticles are promising candidates for gene delivery. The immobilization of enzymes on magnetic nanoparticles helps to increase the enzyme activity and stability which enhances their applicability in bioreactors and biosensors. Magnetically responsive microspheres can be used in bio-separation techniques to remove cells and molecules. Magnetic bead-based immunoassay can be applied to bio-molecule detection and analysis systems. Magnetic polymeric microspheres have the capacity to bind biological molecules which helps to separate RBC from the whole blood. Magnetic arterial embolization hyperthermia can target liver cancers through duel effects of local hyperthermia and arterial embolization. Magnetic nanoparticles is also a good tool for the treatment of water polluted with metal and organic materials.q