Author(s): B. Maheswari Reddy, C. K. Dhanapal, B.V.S. Lakshmi

Email(s): mahi.unaj@gmail.com

DOI: 10.5958/0974-360X.2019.00323.8   

Address: B. Maheswari Reddy1*, C. K. Dhanapal2, B.V.S. Lakshmi1
1Department of Pharmacology, Malla Reddy College of Pharmacy, Dhulapally, Maisamaguda, Secunderabad 500100, Medchal, Telangana, India.
2Department of Pharmacy, Annamalai University, Chidambaram, T.N., India.
*Corresponding Author

Published In:   Volume - 12,      Issue - 4,     Year - 2019


ABSTRACT:
Objective: The present study was aimed to evaluate the protective effect of Murraya koenigii on aluminium chloride (AlCl3) induced neurobehavioral and pathological changes in Alzheimeric rats. Methods: Wistar albino rats were selected in this study and were divided into 6 groups (6each). Group I animals received saline and were considered as control. Group II rats were administered with AlCl3 (40mg/kg b.w, oral) for 35 days. Group III rats were treated with standard Vitamin E (100mg/kg b.w, p.o) and AlCl3 (40mg/kg b.w, oral). Group IV, V,VI received aqueous extract of leaves of Murraya koenigii (100mg/kg b.w, p.o,200mg/kg b.w, p.o,400mg/kg b.w, p.o) and inducing agent AlCl3 (40mg/kg b.w, oral) .The rats were given respective treatment for 35 days and behavioural parameters were determined on the 35th day. On the 35th day the rats were sacrificed and anti-oxidant parameters, brain acetylcholinesterase content were determined. Results: Oral administration of aqueous extract of leaves of Murraya koenigii at doses 100,200, 400mg/kg body weight showed improvements in behavioural parameters when compared to AlCl3 induced rats; showed increase in superoxide dismutase, catalase, reduced glutathione and decreased levels of malondialdehyde and also a showed decrease in brain acetylcholinesterase content when compared to AlCl3 induced rats. Conclusion: This study strongly suggested that M koenigii could possibly restore the altered neurological capacities and antioxidant power in rats, and it could even be a good alternative to chemical medicines against AlCl3 induced neurotoxicity


Cite this article:
B. Maheswari Reddy, C. K. Dhanapal, B.V.S. Lakshmi. Anti-Alzheimer's Activity of aqueous extract of leaves of Murraya koenigii in Aluminium chloride Induced Neurotoxicity in rats. Research J. Pharm. and Tech. 2019; 12(4):1927-1934. doi: 10.5958/0974-360X.2019.00323.8

Cite(Electronic):
B. Maheswari Reddy, C. K. Dhanapal, B.V.S. Lakshmi. Anti-Alzheimer's Activity of aqueous extract of leaves of Murraya koenigii in Aluminium chloride Induced Neurotoxicity in rats. Research J. Pharm. and Tech. 2019; 12(4):1927-1934. doi: 10.5958/0974-360X.2019.00323.8   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2019-12-4-78


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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