ABSTRACT:
Tumour Necrosis Factor (TNF), being an endogenous pyrogen, is able to induce fever, apoptotic cell death, cachexia, inflammation and to inhibit tumourigenesis. TNF has been shown to mediate carcinogenesis through induction of proliferation, invasion, and metastasis of tumour cells. Polymorphisms within TNF genes can result in pathogenesis and promoting malignant progression of cervix cancer. In the present hospital based case-control study, 230 cervix cancer patients (cases) and 230 controls were studied to determine the association of TNF-308 gene polymorphism with cervical cancer. TNF-308 null genotype showed significance distribution among cases and control (?2=18.759, df =2, p = 0.00008). Women carrying the heterozygous A allele had a two-fold increased risk of developing cervix cancer (OR=1.775; 95% CI [1.178-2.674]) while the risk of cervix cancer raises to three-fold when A allele is preset in homozygous condition (OR=3.186; 95% CI [1.775-5.719]). These findings indicate that TNF-308 polymorphisms play crucial role in the development of cervix cancer.