Author(s): Bhabani Shankar Nayak, Harekrishna Roy, Subas Chandra Dinda, P. Ellaiah

Email(s): hareroy92@gmail.com

DOI: 10.5958/0974-360X.2019.00624.3   

Address: Bhabani Shankar Nayak1*, Harekrishna Roy2, Subas Chandra Dinda3, P. Ellaiah4
1Department of Pharmaceutics, Institute of Pharmacy and Technology, Salipur, Cuttack-754202, Odisha, India.
2Department of Pharmaceutics, Nirmala College of Pharmacy, Mangalagiri Mandal, Guntur – 522503, A.P., India.
3Department of Pharmacy, College of Health Sciences, Mekelle University - 1871, Mekelle, Ethiopia.
4Department of Pharmaceutical Technology, Jeypore College of Pharmacy, Rondapalli, Jeypore -764002, Koraput, Odisha, India.
*Corresponding Author

Published In:   Volume - 12,      Issue - 8,     Year - 2019


ABSTRACT:
Aim: The flavonoid compound (Acacetin) isolated from fruits of Gmelina arborea was investigated for its pharmacokinetic evaluation to find out the suitability of this compound to be formulated in any suitable dosage form. Method: The acacetin was administered intravenously and orally in Wistar rats at a dose of 2 and 10 mg/Kg body weight respectively. In a regular interval of specified time, blood samples were collected and bio-analyzed to quantify the drug concentration in the blood sample by using LC-MS. The Cmax, Tmax, T1/2, KE, Ka, and bioavailability (F) of acacetin were determined by mathematically and graphically from plasma concentration-time profile data. Absorption rate constant was determined by the method of residual. Results: From the i.v. Bolus administration data, acacetin had an area under curve (AUC) is 1.542 µg.h/ml, elimination rate constant (KE) is 0.423 h-1, and half-life (T1/2) is two hour. The oral administration of acacetin showed the peak plasma concentration (Cmax) of 1.668 µg/ml, Tmax is 1 h, AUC is 6.44 µg h/ml, KE is 0.416 h-1, T1/2 is 2 h, absorption rate constant (Ka) is 1.6 h and bioavailability of acacetin was found to be 84 %. Conclusion: From the study it could be concluded that the acacetin possessed relatively greater bioavailability; thus this drug exhibited significant satisfactory pharmacokinetic profile which would be helpful for successful designing of a suitable dosage form formulation.


Cite this article:
Bhabani Shankar Nayak, Harekrishna Roy, Subas Chandra Dinda, P. Ellaiah. Pharmacokinetic Evaluation of Flavonoid compound (acacetin) Isolated from Gmelina arborea roxb. Research J. Pharm. and Tech 2019; 12(8):3659-3663. doi: 10.5958/0974-360X.2019.00624.3

Cite(Electronic):
Bhabani Shankar Nayak, Harekrishna Roy, Subas Chandra Dinda, P. Ellaiah. Pharmacokinetic Evaluation of Flavonoid compound (acacetin) Isolated from Gmelina arborea roxb. Research J. Pharm. and Tech 2019; 12(8):3659-3663. doi: 10.5958/0974-360X.2019.00624.3   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2019-12-8-14


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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