Author(s):
S. Hemchand, R. Ravi Chandra Babu, Mukthinuthalapati Mathrusri Annapurna
Email(s):
Hemchand.suryadevara@gmail.com
DOI:
10.5958/0974-360X.2019.00719.4 
Address:
S. Hemchand*1, R. Ravi Chandra Babu1, Mukthinuthalapati Mathrusri Annapurna2
1GITAM Institute of Science, GITAM (Deemed to be University), Visakhapatnam, India
2GITAM Institute of Pharmacy, GITAM (Deemed to be University), Visakhapatnam, India
*Corresponding Author
Published In:
Volume - 12,
Issue - 9,
Year - 2019
ABSTRACT:
Docetaxel is used for the treatment of castration resistant prostate cancer. Docetaxel is a semi synthetic chemo therapeutic agent extracted from the leaves of Taxus baccata. Two process related substances and four impurities were separated and quantified using Sunfire C18 column (250 x 4.6 mm, 5µm particle size) on gradient mode (40 ± 5°C). A mixture of acetonitrile: 0.01 % Acetic acid was used as mobile phase and a mixture of acetonitrile: methanol (1:1, v/v) was used as diluent and the compounds were monitored at 230 nm. Forced degradation studies were performed and the method was validated as per ICH guidelines.
Cite this article:
S. Hemchand, R. Ravi Chandra Babu, Mukthinuthalapati Mathrusri Annapurna. New Validated Stability-Indicating RP-HPLC Method for The Determination of Docetaxel and Its Related Substances. Research J. Pharm. and Tech 2019; 12(9):4165-4181. doi: 10.5958/0974-360X.2019.00719.4
Cite(Electronic):
S. Hemchand, R. Ravi Chandra Babu, Mukthinuthalapati Mathrusri Annapurna. New Validated Stability-Indicating RP-HPLC Method for The Determination of Docetaxel and Its Related Substances. Research J. Pharm. and Tech 2019; 12(9):4165-4181. doi: 10.5958/0974-360X.2019.00719.4 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2019-12-9-19