ABSTRACT:
Study was to investigates antimicrobial properties against clinical isolates of human pathogen, physiochemical and Phytochemical analysis of Acalypha indica. The aqueous, methanol, acetone and chloroform fractions of Acalypha indica were investigated for antimicrobial properties using pathogenic species of 18 bacteria and 8 fungi. Efficacy of antimicrobial properties were shown by all fraction. Significant antimicrobial properties were observed by disc diffusion assay and Microbroth dilution assay against tested pathogen such as Staphylococcus epidermidis, Staphylococcus epidermidis, Streptococcus pyrogens, Salmonella typhi, Bacillus cereus, Escherichia coli, P. aeurigonosa, S. aureus, A. fumigatus, A. flavus, A. niger, C. albicans and C. tropicals. The MICs by microbroth dilution assay was found to be ranged from 0.625 to 10.0 mg/ml in most of the fractions. Chloroform extract was found to be least active against the fungal pathogens. All the fractions of Acalypha indica were exhibited moderate to high activity against human pathogenic microbes; so that, identification of various extracts may be useful in novel antimicrobial compound having less toxicity with high sensitivity and specificity.