ABSTRACT:
Background/Objectives: This study examines the microstructural characteristics of HPV-infected koilocytes microscope taken from the smear test of women’s vaginal cells and the shape of HPV particles under a light. Methods/Statistical analysis: Koilocytes infected with human papilloma virus were stained with Papanicolaou’s method and examined by light microscopy. Ultrastructural characteristics of human papilloma virus inside the koilocyte were identified using transmission electron microscopy. Findings: The cytoplasm of a koilocyte infected with activated virus was filled with keratin filaments and some vacuoles and ribosomes. Activated HPV particles were clearly observed inside the nucleus. These virus particles were identified as spherical, with a diameter of 50 nm, and were mainly around nuclear membrane and nucleus. Improvements/Applications: This study identified that, as HPV invades and proliferates inside the nucleus of epithelial cells, the dysplasia of epithelial cells into koilocytes by forming a nucleophilic zone.