ABSTRACT:
In the present investigation, chitosan (CS) encapsulated naringenin (NARN) nanoparticles (CS-NPs/NARN) were synthesized by ionic gelation method intervened by tripolyphosphate (TPP) as a cross-linker further, compatibility studies i.e., Differential scanning calorimetry, Fourier transform infrared spectroscopy (FTIR) were carried out followed by characterization studies like particle size, SEM, Zeta potential. The encapsulation efficiency and drug content of CS-NPs/NARN was resolved. The particle size of CS-NPs/NARN was observed to be 233nm. The encapsulation efficiency of CS-NPs/NARN was distinguished to be ~72% for the best formulation NC2. The release of NARN from CS-NPs/NARN in simulated gastric fluid was found to be ~89%. CS-NPs/NARN prepared to improve the treatment of neurotoxicity caused by neurotoxicants. Thus, Physicochemical properties suggested the potential outcome of enhancement of penetration across blood brain barrier (BBB) for the improved treatment of neurotoxicity due to its potent antioxidant activity having a possibility to reduce the neurotoxicty induced abnormalities in brain. Further studies regarding current work may give noticeable outcomes.