Author(s):
Mudjiani Basuki, Muhammad Hamdan, Fidiana, Fadil, Irma Rizkika Marjianto
Email(s):
mudjianibasuki001@gmail.com
DOI:
10.5958/0974-360X.2020.00934.8 
Address:
Mudjiani Basuki1*, Muhammad Hamdan1, Fidiana1, Fadil1, Irma Rizkika Marjianto1
1Department of Neurology, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo Teaching Hospital, Surabaya 60285, Indonesia.
*Corresponding Author
Published In:
Volume - 13,
Issue - 11,
Year - 2020
ABSTRACT:
Guillain-barre syndrome (GBS) is a common cause of acute severe paralysis. This weakness makes people with GBS could not move for a long time, thus disrupting the productivity of the patient. GBS usually occurs after an infectious disease in which the immune response produces cross-reacting antibodies with gangliosides in the neural membrane. Seasonal variations in GBS could be caused by the season of infectious disease that proceeds and it affects the weight of GBS. The study was conducted retrospectively, case-control study, using the hospitalized patient records of GBS patients in Dr. Soetomo Teaching Hospital, Surabaya, which meets the inclusion and exclusion criteria, from January 2013 to October 2016. GBS severity is assessed using the Medical research council (MRC) sum score. The case group was GBS with a severe severity which has a value <36. There were 82 subjects that consist of 41 case groups and 41 control groups. In the case group with the onset of transition symptoms during the transition season, there were 21 people 51.2% more than 15 the control group 36.6%. In contrast, in the control group, the onset symptom was not the transition season, 26 people 63.4% than the case group of 20 people 48.8%. However, this difference was not statistically significant with p = 0.182 and research objectives (RO) 1.82 (CI 95% 0.753-4.399). There was no correlation between the transmission season and the severity of GBS.
Cite this article:
Mudjiani Basuki, Muhammad Hamdan, Fidiana, Fadil, Irma Rizkika Marjianto. Association between Transmission Season and Degree of Severity in Guillain-Barre Syndrome. Research J. Pharm. and Tech. 2020; 13(11):5345-5348. doi: 10.5958/0974-360X.2020.00934.8
Cite(Electronic):
Mudjiani Basuki, Muhammad Hamdan, Fidiana, Fadil, Irma Rizkika Marjianto. Association between Transmission Season and Degree of Severity in Guillain-Barre Syndrome. Research J. Pharm. and Tech. 2020; 13(11):5345-5348. doi: 10.5958/0974-360X.2020.00934.8 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2020-13-11-49
REFERENCES:
1. Van Den Berg B, Walgaard C, Drenthen J, Fokke C, Jacobs BC, Van Doorn PA. Guillain–Barré syndrome: pathogenesis, diagnosis, treatment and prognosis. Nat Rev Neurol. 2014;10(8):469.
2. Japardi I. Sindroma Guillain-Barre. 2002;
3. Yadegari S, Kazemi N, Nafissi S. Clinical and electrophysiological features of Guillain–Barré syndrome in Iran. J Clin Neurosci. 2014;21(9):1554–7.
4. Sriganesh K, Netto A, Kulkarni GB, Taly AB, Rao GSU. Seasonal variation in the clinical recovery of patients with Guillain Barré syndrome requiring mechanical ventilation. Neurol India. 2013;61(4):349.
5. Webb AJS, Brain SAE, Wood R, Rinaldi S, Turner MR. Seasonal variation in Guillain-Barré syndrome: a systematic review, meta-analysis and Oxfordshire cohort study. J Neurol Neurosurg Psychiatry. 2015;86(11):1196–201.
6. McGrogan A, Madle GC, Seaman HE, De Vries CS. The epidemiology of Guillain-Barré syndrome worldwide. Neuroepidemiology. 2009;32(2):150–63.
7. Haghighi AB, Banihashemi MA, Zamiri N, Sabayan B, Heydari ST, Safari A, et al. Seasonal variation of Guillain-Barre syndrome admission in a large tertiary referral center in southern Iran: a 10 year analysis. Acta Neurol Taiwan. 2012;21(2):60–6321.
8. van Doorn PA. Diagnosis, treatment and prognosis of Guillain-Barré syndrome (GBS). Presse Med. 2013;42(6):e193–201.
9. Van Doorn PA, Ruts L, Jacobs BC. Clinical features, pathogenesis, and treatment of Guillain-Barré syndrome. Lancet Neurol. 2008;7(10):939–50.
10. Rivera‐Lillo G, Torres‐Castro R, Burgos PI, Varas‐Díaz G, Vera‐Uribe R, Puppo H, et al. Incidence of Guillain‐Barré syndrome in Chile: a population‐based study. J Peripher Nerv Syst. 2016;21(4):339–44.
11. Dourado ME, Félix RH, da Silva WKA, Queiroz JW, Jeronimo SMB. Clinical characteristics of Guillain–Barré syndrome in a tropical country: a Brazilian experience. Acta Neurol Scand. 2012;125(1):47–53.
12. Kalita J, Misra UK, Goyal G, Das M. Guillain‐Barré syndrome: subtypes and predictors of outcome from India. J Peripher Nerv Syst. 2014;19(1):36–43.
13. Blum S, Reddel S, Spies J, McCombe P. Clinical features of patients with Guillain‐Barré syndrome at seven hospitals on the East Coast of Australia. J Peripher Nerv Syst. 2013;18(4):316–20.
14. Gunasekera SM, Gunarathna K, Samarawickrama D, Dharmakeerthi DMW, Sesath HGR, Wijesekera RL, et al. Guillain-Barre syndrome in Sri Lanka: subtypes and trends. SRI LANKA J Neurol. :10.
15. McKhann GM, Cornblath DR, Griffin JW, Ho TW, Li CY, Jiang Z, et al. Acute motor axonal neuropathy: a frequent cause of acute flaccid paralysis in China. Ann Neurol. 1993;33(4):333–42.
16. Chroni E, Papapetropoulos S, Gioldasis G, Ellul J, Diamadopoulos N, Papapetropoulos T. Guillain–Barré syndrome in Greece: seasonality and other clinico‐epidemiological features. Eur J Neurol. 2004;11(6):383–8.
17. Goh KJ, Ng WK, Vaithialingam M, Tan CT. A clinical and electrophysiological study of Guillain-Barré syndrome in Malaysia. Neurol J Southeast Asia. 1999;4:67–72.