Author(s):
Sunita, Vikas Budhwar, Manjusha Choudhary
Email(s):
vikaasbudhwar@yahoo.com , manjushachoudhary@gmail.com
DOI:
10.5958/0974-360X.2020.00963.4 
Address:
Sunita1, Dr. Vikas Budhwar1, Dr. Manjusha Choudhary2
1Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, India-124001.
2Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra.
*Corresponding Author
Published In:
Volume - 13,
Issue - 11,
Year - 2020
ABSTRACT:
Eutectics mixture, amongst other binary systems like cocrystals, solid dispersion, solid solution and inclusion complexes can be utilised to simultaneously enhance more than one characteristics of drugs like dissolution, permeability, stability etc. So far their utility is exploited to a large pace in metallurgy, however very little is achieved in the field of pharmaceuticals. References suggests that eutectics can be made very easily (sometimes spontaneously) both on laboratory scale as well as on industrial scale. The present review comprehensively and succinctly presents vital information like criteria of historical background formation, method of preparation and evaluation parameter of eutectics, which would help to exploit them in the pharmaceutical field.
Cite this article:
Sunita, Vikas Budhwar, Manjusha Choudhary. Pharmaceutical Eutectics: A Promising Drug Delivery System. Research J. Pharm. and Tech. 2020; 13(11):5515-5523. doi: 10.5958/0974-360X.2020.00963.4
Cite(Electronic):
Sunita, Vikas Budhwar, Manjusha Choudhary. Pharmaceutical Eutectics: A Promising Drug Delivery System. Research J. Pharm. and Tech. 2020; 13(11):5515-5523. doi: 10.5958/0974-360X.2020.00963.4 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2020-13-11-78
REFERENCES:
1. Cherukuvada S, Nangia A. Eutectics as improved pharmaceutical materials: Design, properties and characterization. Chem Commun. 2014; 50(8):906–23.
2. Gala U, Chuong MC, Varanasi R, Chauhan H. Characterization and Comparison of Lidocaine-Tetracaine and Lidocaine-Camphor Eutectic Mixtures Based on Their Crystallization and Hydrogen-Bonding Abilities. AAPS PharmSciTech [Internet]. 2015; 16(3):528–36. Available from: http://link.springer.com/10.1208/s12249-014-0242-4
3. Law D, Wang W, Schmitt EA, Qiu Y, Krill SL, Fort JJ. Properties of rapidly dissolving eutectic mixtures of poly(ethylene glycol) and fenofibrate: The eutectic microstructure. J Pharm Sci. 2003; 92(3):505–15.
4. Baird JA, Taylor LS. Evaluation and modeling of the eutectic composition of various drug-polyethylene glycol solid dispersions. Pharm Dev Technol. 2011; 16(3):201–11.
5. Kumari A, Prajapati SK, Niranjan P. Solubility enhancement studies of solid dispersion. World J Pharm Pharm Scienes. 2015; 4(10):2126–42.
6. Argade PS, Magar DD. Solid Dispersion : Solubility Enhancement Technique for poorly water soluble Drugs. J Advanced Pharmarcy Educ Res. 2013; 3:427–39.
7. Dalal N, Buckner IS, Wildfong PLD. Experimental Determination and Theoretical Calculation of the Eutectic Composition of Cefuroxime Axetil Diastereomers. AAPS PharmSciTech [Internet]. 2017; 18(7):2570–8. Available from: http://link.springer.com/10.1208/s12249-017-0739-8
8. Sikarra D, Shukla V, Kharia AA, Chatterjee DP. Techniques for Solubility Enhancement of Poorly Soluble Drugs: an Overview. J Med Pharm www.jmpas.com Allied Sci J Med Pharm Allied Sci J Med Pharm Allied Sci. 2012; 01(01):1–22.
9. Hoang Pham UG. Pharmaceutical Applications of Eutectic Mixtures. J Dev Drugs [Internet]. 2013; 02(03):2–3. Available from: http://www.omicsgroup.org/journals/pharmaceutical-applications-of-eutectic-mixtures-2329-6631.1000e130.php?aid=21739
10. Kim SH, Park S, Yu H, Kim JH, Kim HJ, Yang YH, et al. Effect of deep eutectic solvent mixtures on lipase activity and stability. J Mol Catal B Enzym [Internet]. 2016; 128:65–72. Available from: http://dx.doi.org/10.1016/j.molcatb.2016.03.012
11. Vasconcelos T, Sarmento B, Costa P. Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs. Drug Discov Today. 2007; 12(23–24):1068–75.
12. Hou Y, Gu Y, Zhang S, Yang F, Ding H, Shan Y. Novel binary eutectic mixtures based on imidazole.J Mol Liq. 2008;143(2–3);154–9.
13. Abbott AP, Ahmed EI, Prasad K, Qader IB, Ryder KS. Liquid pharmaceuticals formulation by eutectic formation. Fluid Phase Equilib. 2017;
14. Thipparaboina R, Thumuri D, Chavan R, Naidu VGM, Shastri NR. Fast dissolving drug-drug eutectics with improved compressibility and synergistic effects. Eur J Pharm Sci [Internet]. 2017; 104:82–9. Available from: http://dx.doi.org/10.1016/j.ejps.2017.03.042
15. Przybyłek M, Cysewski P. Distinguishing Cocrystals from Simple Eutectic Mixtures: Phenolic Acids as Potential Pharmaceutical Coformers. Cryst Growth Des. 2018; 18(6):3524–34.
16. Goud NR, Suresh K, Sanphui P, Nangia A. Fast dissolving eutectic compositions of curcumin. Int J Pharm [Internet]. 2012; 439(1–2):63–72. Available from: http://dx.doi.org/10.1016/j.ijpharm.2012.09.045
17. Passerini N, Albertini B, González-Rodríguez ML, Cavallari C, Rodriguez L. Preparation and characterisation of ibuprofen-poloxamer 188 granules obtained by melt granulation. Eur J Pharm Sci. 2002; 15(1):71–8.
18. Yong CS, Oh YK, Jung SH, Rhee JD, Kim HD, Kim CK, et al. Preparation of ibuprofen-loaded liquid suppository using eutectic mixture system with menthol. Eur J Pharm Sci. 2004; 23(4–5):347–53.
19. Youn SH, Park HW, Choe D, Shin CS. Preparation of eutectic substrate mixtures for enzymatic conversion of ATC to L-cysteine at high concentration levels. Bioprocess Biosyst Eng. 2014; 37(6):1193–200.
20. Urbanetz NA. Stabilization of solid dispersions of nimodipine and polyethylene glycol 2000. Eur J Pharm Sci. 2006; 28(1–2):67–76.
21. Cherukuvada S, Guru Row TN. Comprehending the formation of eutectics and cocrystals in terms of design and their structural interrelationships. Cryst Growth Des. 2014; 14(8):4187–98.
22. Leuner C, Dressman J. Improving drug solubility for oral delivery using solid dispersions. Eur J Pharm Biopharm [Internet]. 2000; 50(1):47–60. Available from: http://www.ncbi.nlm.nih.gov/pubmed/10840192
23. Cherukuvada S, Nangia A. Fast dissolving eutectic compositions of two anti-tubercular drugs. CrystEngComm. 2012; 14(7):2579–88.
24. Bi M, Hwang SJ, Morris KR. Mechanism of eutectic formation upon compaction and its effects on tablet properties. Thermochim Acta. 2003; 404(1–2):213–26.
25. Chiou WL, Riegelmant S. Pharmaceutical sciences Pharmaceutical Applications of Solid. J Pharm Sci. 1971; 60(9):1281–302.
26. Han SH. Stability of a eutectic interface during directional solidification. 1995;
27. Stoler E, Warner JC. Non-Covalent derivatives: Cocrystals and eutectics. Molecules. 2015; 20(8):14833–48.
28. Vippagunta SR, Wang Z, Hornung S, Krill SL. Factors affecting the formation of eutectic solid dispersions and their dissolution behavior. J Pharm Sci. 2007;
29. Kaplun-Frischoff Y, Touitou E. Testosterone skin permeation enhancement by menthol through formation of eutectic with drug and interaction with skin lipids. J Pharm Sci. 1997; 86(12):1394–9.
30. Avula SG, Alexander K, Riga A. Predicting eutectic behavior of drugs and excipients by unique calculations. J Therm Anal Calorim. 2010; 99(2):655–8.
31. Hsu EC-H, Johnson JF. Prediction of Eutectic Temperatures, Compositions and Phase Diagrams for Binary Mesophase Systemst. Mol Cryst Liq Cryst [Internet]. 1974; 27(1–2):95–104. Available from: https://www.tandfonline.com/doi/full/10.1080/15421407408083122
32. Simeonov SP, Afonso CAM. Basicity and stability of urea deep eutectic mixtures. RSC Adv. 2016; 6(7):5485–90.
33. Sharma S, Kumar A, Singh V. Dependence of Eutectic - Composition on Densities of Components of Binary Eutectic Mixtures of Solid Carboxylic Acids. J Appl Chem. 2012; 3(1):18–22.
34. Pan RN, Chen JH, Chen RRL. Enhancement of dissolution and bioavailability of piroxicam in solid dispersion systems. Drug Dev Ind Pharm. 2000; 26(9):989–94.
35. Nidhi K, Indrajeet S, Khushboo M, Gauri K, Sen DJ. Hydrotropy: A promising tool for solubility enhancement: A review. Int J Drug Dev Res. 2011; 3(2):26–33.
36. Löbmann K, Laitinen R, Grohganz H, Gordon KC, Strachan C, Rades T. Coamorphous drug systems: Enhanced physical stability and dissolution rate of indomethacin and naproxen. Mol Pharm. 2011; 8(5):1919–28.
37. Ma G, Wang Z, Xie S, Sun J, Jia Y, Jing Y, et al. Preparation and Properties of Stearic Acid–Acetanilide Eutectic Mixture/Expanded Graphite Composite Phase-Change Material for Thermal Energy Storage. Energy Technol. 2018; 6(1):153–60.
38. Shin D, Banerjee D. Enhanced Specific Heat Capacity of Nanomaterials Synthesized by Dispersing Silica Nanoparticles in Eutectic Mixtures. J Heat Transfer [Internet]. 2013; 135(3):032801. Available from: http://heattransfer.asmedigitalcollection.asme.org/article.aspx?doi=10.1115/1.4005163
39. Cai Y, Ke H, Lin L, Fei X, Wei Q, Song L, et al. Preparation, morphology and thermal properties of electrospun fatty acid eutectics/polyethylene terephthalate form-stable phase change ultrafine composite fibers for thermal energy storage. In: Energy Conversion and Management. 2012.
40. Zhang X, Huang Z, Yin Z, Zhang W, Huang Y, Liu Y, et al. Form stable composite phase change materials from palmitic-lauric acid eutectic mixture and carbonized abandoned rice: Preparation, characterization, and thermal conductivity enhancement. Energy Build [Internet]. 2017; 154:46–54. Available from: https://doi.org/10.1016/j.enbuild.2017.08.057
41. Figueirêdo CBM, Nadvorny D, de Medeiros Vieira ACQ, Soares Sobrinho JL, Rolim Neto PJ, Lee PI, et al. Enhancement of dissolution rate through eutectic mixture and solid solution of posaconazole and benznidazole. Int J Pharm [Internet]. 2017; 525(1):32–42. Available from: http://dx.doi.org/10.1016/j.ijpharm.2017.04.021
42. Zaini E, Wahyuni YS, Halim A, Yuliandra Y. Preparation of eutectic mixture of ketoprofen and nicotinamide for enhanced dissolution rate. Int J Pharm Sci Rev Res. 2015; 35(1):161–4.
43. Skieneh J, Rohani S. Screening New Solid Forms of Pharmaceuticals to Enhance Solubility and Dissolution Rate. Austin Pharmacol Pharm. 2017; 2(1):1007.
44. Luo Z, Zhang H, Gao X, Xu T, Fang Y, Zhang Z. Fabrication and characterization of form-stable capric-palmitic-stearic acid ternary eutectic mixture/nano-SiO2composite phase change material. Energy Build [Internet]. 2017; 147:41–6. Available from: http://dx.doi.org/10.1016/j.enbuild.2017.04.005
45. Zhao H, Ge M, Wang W, Li Q, Yu X. Application of Teraherz Time Domain Spectroscopy in chemistry and biology. Chem Bull / Huaxue Tongbao. 2005