Author(s):
Rahul S Solunke, Ganesh A Khade, Krishnmurthy, M T Deshmukh, R V. Shete, K J Kore
Email(s):
gkhade738@gmail.com
DOI:
10.5958/0974-360X.2020.00131.6 
Address:
Rahul S Solunke1, Ganesh A Khade2*, Krishnmurthy3, M T Deshmukh4, R V. Shete5, K J Kore6
1Department of Pharmaceutic’s, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor, Pune 412206 Maharshtra India
2Department of Pharmaceutic’s, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor, Pune 412206 Maharshtra India
3Department of Pharmacology, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor, Pune 412206, Maharashtra, India.
4Department of Pharmaceutic’s, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor, Pune 412206 Maharshtra India
5Department of Pharmacology, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor, Pune 412206, Maharashtra, India.
*Corresponding Author
Published In:
Volume - 13,
Issue - 2,
Year - 2020
ABSTRACT:
Objective: The current investigation is to development andevaluation of HPMC based floating oral In situ gel of Pantoprazole Sodium. Method: Six formulations were formulate 2*3 factorial design .batch F-6 gives newer alternatives use of natural biodegradable polymer in situ gel formulation.Drug , Excipients and polymer compatibility studies were performed by FTIR and DSC. Result: The formulation was optimized gelling capacity, drug contentrange 92.93±0.10%to 96.83±.0.15%.percentage yield is 64.00%, 75.93%, 87.83%, .93.21% and 95.25% and 97.07 % respectively.The consistency of all the formulations was in the range 5.0±0.1 to 7.1±0.1 mm.The consistency of all the formulations.the formulated gel The pH of all the formulations was found to be 6.5 ±1.0.viscosity 1.440,1.500,1.560,3.708,3.182,4.000 Conclusion: It is to obtain the increased residence time and sustained drug release.The gel formed in situ afforded sustained drug release over 8 hrs periods. The formulations exhibited therapeutic efficacy.
Cite this article:
Rahul S Solunke, Ganesh A Khade, Krishnmurthy, M T Deshmukh, R V. Shete, K J Kore. Development and Evaluation of Pantoprazole Sodium Floating Gel. Research J. Pharm. and Tech 2020; 13(2):682-686. doi: 10.5958/0974-360X.2020.00131.6
Cite(Electronic):
Rahul S Solunke, Ganesh A Khade, Krishnmurthy, M T Deshmukh, R V. Shete, K J Kore. Development and Evaluation of Pantoprazole Sodium Floating Gel. Research J. Pharm. and Tech 2020; 13(2):682-686. doi: 10.5958/0974-360X.2020.00131.6 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2020-13-2-35