ABSTRACT:
Aim and Objective: The purpose of the study is to evaluate the antiulcer activity on methanolic extract of Barleria buxifolia L (MEBB) in experimental animals. Material and Method: The antiulcer activity was evaluated against pylorus ligation and aspirin induced ulcers in wistar rats. The MEBB was administered orally at a dose of 200 mg/kg and 400 mg/kg in rats. Omeprazole (20 mg/kg) was used as standard drug and 1% CMC and aspirin (250 mg/kg) were used in control group. Results: Preliminary phytochemical screening revealed the presence of several bioactive compounds. No mortality rate in rats were found upto 4000 mg/kg dose. The MEBB produced significant decrease in gastric juice volume, free acidity, total acidity, total acid output, ulcer score and ulcer index but increase in gastric juice pH in both models when compared to control group. It produced 69.01% and 68.11% ulcer inhibition in pylorus ligation and aspirin induced method. It also produced significant results for antioxidant parameters. The obtained results were due to the presence of flavonoids in MEBB which produce antisecretory effect. Conclusion: The obtained results revealed that the MEBB exhibits antiulcer activity in wistar rats. The high dose (400 mg/kg) of MEBB gives significant results when compared to low dose (200 mg/kg) of MEBB.