ABSTRACT:
Rheumatoid arthritis (RA) is an autoimmune disease of inflammatory origin. It progressively affects the articular and extra-articular joints, mostly identified by hyperplasia, inflammation of synoviocytes, autoantibody production and bone/cartilage degradation. Etiology and underlying mechanism of RA is still unknown, causing an imbalance between inflammatory and anti-inflammatory pathways. The drawbacks in the safety, efficacy of existing treatment options, are driving the need for new, effective and safe medications. As, it is a priority for biological research in 21st century, current experimental outcomes focus on the potential of Nutraceutical in management of RA. Furthermore, we abridge the effect of various citrus flavonoids against Rheumatoid arthritis with main biochemical citations which can either improve or retard the RA by their, anti-inflammatory, anti-oxidant, anti-radical, immuno modulatory and enzyme inhibitory effects. The main aim of this review is to perform an up-to-date insight regarding pathophysiological basis of RA. A special focus is given on the effective dietary Nutraceutical, particularly effect of flavonoids (citrus) on prevention of the progression of Rheumatoid Arthritis. Finally, by using several plethora of evidence, this review suggests the promising future prospects of various dietary citrus flavonoids, their underlying mechanisms, which are having massive potential to be explored as safe and effective treatment strategies in RA.