Author(s): G. Islam, Kavita Gahlot, Munesh Mani, Prevesh Kumar, Divaker Shukla

Email(s): gayyurul.islam@gmail.com

DOI: 10.5958/0974-360X.2020.00218.8   

Address: G. Islam1, Kavita Gahlot2, Munesh Mani1, Prevesh Kumar1, Divaker Shukla1
1Faculty of Pharmacy, IFTM University, Moradabad-244102, Uttar Pradesh, India.
2School of Pharmaceutical Sciences, IFTM University.
*Corresponding Author

Published In:   Volume - 13,      Issue - 3,     Year - 2020


ABSTRACT:
The present study was conducted to evaluate the hepatoprotective activity of ethanolic extract of Leucas cephalotes against Paracetamol induced liver damage in rats. The ethanolic extract of Leucas cephalotes (600mg/kg) was administered orally to the animals with hepatotoxicity induced by Paracetamol (3gm/kg). Silymarin (25mg/kg) was given as reference standard. All the test drugs were administered orally by suspending in 0.5% Carboxy methyl cellulose solution. The plant extract was effective in protecting the liver against the injury induced by Paracetamol in rats. This was evident from significant reduction in serum enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and bilirubin. It was concluded from the result that the ethanolic extract of Leucas cephalotes possesses hepatoprotective activity against Paracetamol induced hepatotoxicity in rats.


Cite this article:
G. Islam, Kavita Gahlot, Munesh Mani, Prevesh Kumar, Divaker Shukla. Hepatoprotective Activity of Leucas cephalotes against Paracetamol induced Hepatotoxicity in Rats. Research J. Pharm. and Tech 2020; 13(3):1183-1186. doi: 10.5958/0974-360X.2020.00218.8

Cite(Electronic):
G. Islam, Kavita Gahlot, Munesh Mani, Prevesh Kumar, Divaker Shukla. Hepatoprotective Activity of Leucas cephalotes against Paracetamol induced Hepatotoxicity in Rats. Research J. Pharm. and Tech 2020; 13(3):1183-1186. doi: 10.5958/0974-360X.2020.00218.8   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2020-13-3-23


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DOI: 10.5958/0974-360X 

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