ABSTRACT:
Antiobesity and antidiabetic exercises of the concentrates of Syzygium cerasoideum were examined by considering the in-vivo impacts of HFD actuated heftiness in C57BL/6 mice and OGTT in Wistar rodents. The counter stoutness and against diabetic impacts of MESC and CESC on HFD incited heftiness in mice were explored for about a month. The oral glucose resilience test has frequently been utilized to assess evident insulin discharge and insulin opposition in different clinical settings. In the present examination, the oral glucose resilience test demonstrates a critical decrease in blood glucose levels of MESC 400mg/kg at 30min contrasted and typical control. The MESC and CESC extracts at various portions assessed against HFD-prompted diabetes/antiobesity in C57BL/6 mice, the results have exhibited that MESC 200 and 400mg/kg have antidiabetic property. The high-fat eating regimen nourished C57BL/6 mice demonstrated critical decrease of body loads on day 21 and 28, glucose and triglyceride levels toward the part of the bargain were factually noteworthy, *p?0.05 when contrasted and the control, *p?0.05 when contrasted and the HFD, shows antidiabetic and antiobesity action of the two concentrates. The MESC (200 and 400mg/kg ) treatment lightened all these metabolic changes like body weight, blood glucose and hyperlipidemia that happened due to HFD.
Cite this article:
Shaik Sadik, Geetha. K.M, Vasia. Syzygium cerasoideum concentrates lessen high - FAT eating routine Instigated Heftiness and Diabetes in C57BL/6 Mice. Research J. Pharm. and Tech 2020; 13(3): 1297-1302. doi: 10.5958/0974-360X.2020.00239.5
Cite(Electronic):
Shaik Sadik, Geetha. K.M, Vasia. Syzygium cerasoideum concentrates lessen high - FAT eating routine Instigated Heftiness and Diabetes in C57BL/6 Mice. Research J. Pharm. and Tech 2020; 13(3): 1297-1302. doi: 10.5958/0974-360X.2020.00239.5 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2020-13-3-44
REFERENCES:
1.
Barness L.A., Opitz
J.M., Gilbert-Barness E. Obesity: Genetic, molecular, and environmental aspects.
Am. J. Med. Genet. Part A. 2007; 143: 3016–3034.
2. Friedman, J.M. Obesity in the new millennium. Nature 2000; 404: 632–634.
3. Hotamisligil, G.S. The role of TNFα and TNF receptors in obesity and insulin
resistance. J. Intern. Med. 1999; 245: 621–625.
4. Shimomura, I. et al. Enhanced expression of PAI-1 in visceral fat: a possible
contributor to vascular disease in obesity. Nature Med. 1996; 2: 800–803.
5. White, R.T. et al. Human adipsin is identical to complement factor D and
is expressed at high levels in adipose tissue. J. Biol. Chem. 1992; 267: 9210–9213.
6. Steppan, C.M. et al. The hormone resistin links obesity to diabetes. Nature
2012; 409:307–312.
7.
Powell A.G., Apovian
C.M., Aronne L.J. New drug targets for the treatment of obesity. Clin.
Pharmacol. Ther. 2011; 90: 40–51.
8.
Lim D.W., Kim Y.T.,
Jang Y.J., Kim Y.O., Han D.S. Anti-obesity effect of Artemisia capillaris extracts in high-fat diet-induced obese rats. Molecules.
2013;18: 9241–9252.
9.
Yun J.W. Possible
anti-obesity therapeutics from nature—A review.
Phytochemistry. 2010; 71:1625–1641.
10.
Haron,
N.W.; Moore, D.M,;Harbome, J.B distribution and taxonomic significance of flavonoids
in the genus Eugenia (myrtaceae) Biochemical systematic and ecology Vol.20, 226-268
(1992).
11.
Mehta
RM Pharmaceutics-1.1st edn, Vallabha
Prakashan, Delhi. (1994) 138-140.
12. Sadik S, Geetha KM
and Vasia: In-vivo antioxidant and antihyperlipidemic activity of Syzygium
cerasoideum extracts in rats. Int J Pharm Sci & Res 2019; 10(6): 1000-1009.
13. Khandelwal KR. Practical
pharmacognosy techniques and experiments. 14th edn, Nirali Prakashan,
Pune. (2005) 149-156.
14. Bartoli, G.P. Fra, G.P. Carnevale Schianca. The oral glucose
tolerance test. European journal of internal medicine 2011; 22: 8-12.
15. Prakasam, A., Sethupathy, S., Pugalendi, K. Effect of Casearia esculent root extract on blood glucose
and plasma antioxidant status in streptozotocin-diabetic rats. Polish Journal of
Pharmacology .2003; 55: 43–49.
16.
Surwit RS, Kuhn CM,
Cochrane C, Mc Cubbin JA, Feinglos MN. Diet-induced type II diabetes in C57BL/6J
mice. Diabetes 1988; 37 : 1163-1167.
17.
Speakman J, Hambly
C, Mitchell S, Krol E. Animal models of obesity. Obes Rev 2007; 8: 55-61.
18.
Winzell MS, Ahren
B. The high-fat diet-fed mouse: a model for studying mechanisms and treatment of
impaired glucose tolerance and type 2 diabetes. Diabetes 2004; 53 : 215-219.
19. Johnson PR, Greenwood MR, Horwitz BA, Stern JS. Animal
models of obesity genetic aspects. Annu Rev Nutr 1991; 11: 325-353.
20.
Mahesh Kumar P, Venkataranganna
MV, Manjunath K, Viswanatha GL, Ashok G. Methanolic extract of Momordica cymbalaria
enhances glucose uptake in L6 myotubes in vitro by up-regulating PPAR-γ and GLUT-4.
Chin J Nat Med 2014; 12: 895-900.
21.
Mahesh Kumar P, Venkataranganna
MV, Manjunath K, Viswanatha GL, Ashok G. Methanolic fruit extract of Momordica cymbalaria
alleviates insulin resistance by enhancing expression of adiponectin and leptin
in vitro. World J Pharm Pharm Sci 2016; 5: 1925-1935.
22.
Iwaki M, Matsuda M,
Maeda N, Funahashi T, Matsuzawa Y, Makishima M, Shimomura I. Induction of adiponectin,
a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors. Diabetes2003;
52: 1655-1663.
23.
Bouskila M, Panjvani
UB, Scherer PE. Adiponectin: a relevant player in PPAR-γ agonist-mediated improvements
in hepatic insulin sensitivity. Int J Obes 2005; 1: S17-S23.
24.
Ronti T, Lupatteli
G, Mannarino E. The endocrine function of adipose tissue: an update. Clin. Endocrinol
2006; 64: 355-365.
25.
Zheng F, Zhang S,
Lu W, Wu F, Yin X, Yu D, Pan Q, Li H. Regulation of insulin resistance and adiponectin
signalling in adipose tissue by liver X receptor activation highlights a cross-talk
with PPAR-γ. PLoS One 2014; 9: e101269.
26.
Flier JS. Obesity
wars: molecular progress confronts an expanding epidemic. Cell 2004; 23: 337-350.
27.
Zhang Y, Proenca R,
Maffei M, Barone M, Leopold L, Friedman JM.
Positional cloning of the mouse obese gene and its human homologue. Nature 1994;
372: 425-432.
28.
Farooqi IS, Matarese
G, Lord GM. Beneficial effects of leptin on obesity, T cell hyporesponsiveness,
and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.
J Clin Invest 2002; 110:1093-1103.