Author(s): Yashpal S Kori, Bhumika Yogi, Sujeet Gupta

Email(s): Koriyashpal@gmail.com

DOI: 10.5958/0974-360X.2020.00246.2   

Address: Yashpal S Kori*, Bhumika Yogi, Sujeet Gupta
Department of Pharmaceutical Chemistry, Hygia Institute of Pharmaceutical Education and Research, Lucknow – 206020 (U.P.), India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 3,     Year - 2020


ABSTRACT:
Objective: The present study evaluates the anti hemorrhoid activity of the ethanolic extract, isolated rutin, and a new rutin derivative semi synthesized from Euphorbia hirta Linn. Methods: Extraction using Soxhlet apparatus to obtain ethanolic extract from the whole plant of Euphorbia hirta Linn. followed by isolation of a vital Flavanoid (rutin), and synthesizing a new rutin derivative. The anti hemorrhoid activity was, evaluated by inducing hemorrhoid using croton oil preparation in Wistar Albino rats. The anti hemorrhoid potential was, determined by recto anal coefficient. The histopathological evaluation was done to evaluate the severity sore between treated and untreated groups. Results: Treatment of the rectoanal cell line for five days with isolated rutin (0.015 ± 0.0023) and semi synthesized drug (0.020 ± 0.0035 *) showed remarkable healing as compared to ethanolic extract 0.020 ± 0.0039 **. Conclusion: The results indicate that Euphorbia hirta Linn could be useful as an anti-hemorrhoid drug, hence from this study, its concluded that ethanolic extract, isolated rutin, and semi-synthesized rutin derivative possess significant anti-hemorrhoid activity, complementary studies should be made to establish its use mainly in India. Further research on rutin for the discovery as a potent anti hemorrhoid agent is required, to synthesize a compound as a useful lead molecule with a better pharmacological profile.


Cite this article:
Yashpal S Kori, Bhumika Yogi, Sujeet Gupta. Antihaemorrhoid Activity of Isolated and Semi – Synthesized Rutin Derivative from Euphorbia hirta Linn. Research J. Pharm. and Tech 2020; 13(3):1333-1338. doi: 10.5958/0974-360X.2020.00246.2

Cite(Electronic):
Yashpal S Kori, Bhumika Yogi, Sujeet Gupta. Antihaemorrhoid Activity of Isolated and Semi – Synthesized Rutin Derivative from Euphorbia hirta Linn. Research J. Pharm. and Tech 2020; 13(3):1333-1338. doi: 10.5958/0974-360X.2020.00246.2   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2020-13-3-51


REFERENCES:

1.     Mullaicharam A.R, et al. A Review, Research J. Pharm. and Tech. 2010; 3(2): 296-299.

2.     Shekhawat M.S. Direct shoots regeneration from explant surface in Euphorbia hirta L. Research J. Pharm. and Tech. 2013 6(4): 435-439.

3.     Meher B, et al. Screening of Methanolic Extract of Euphorbia hirta linn for Antiinflammatory Activity in Experimental Animals. Research J. Pharm. and Tech. 2012; 5 (1): 38-40.

4.     Ganie S.A, et al. Antioxidant activity of Euphorbia hirta L. leaf extracts Research J. Pharm. and Tech. 2018; 11(1): 199-202.

5.     Teeli R.A, et al. Antioxidant activity of Euphorbia hirta L. leaf extracts. Research J. Pharm. and Tech. 2018; 11(1): 199-202

6.     Perera S.D, et al. Potential Use of Euphorbia hirta for Dengue: A Systematic Review of Scientific Evidence. Journal of Tropical Medicine. 2018; 1-7

7.     Ping K.Y, et al. Genotoxicity of Euphorbia hirta: An Allium cepa assay. Molecules. 2012; 17(7): 7782-7791.

8.     Parmar G, et al. Amelioration of anaphylaxis, mast cell degranulation and bronchospasm by Euphorbia hirta L. extracts in experimental animals Beni-Suef University Journal of Basic and Applied Sciences Volume 7, Issue 1, March 2018, Pages 127-134.

9.     Kadiyala G, et al. Protective effect of Euphorbia hirta and its components against snake venom-induced lethality. Journal of Ethnopharmacology. 2015; 165: 180-190.

10. Tiwari N, et al. Anti-stress activity of a Bioflavonoid: Quercetin from Euphorbia hirta. British Journal of Pharmaceutical Research. 2015; 6(2): 68-75.

11. Jakhar S and Dahiya P. Antibacterial, Antioxidant Activity, and Phytochemical Analysis of Euphorbia hirta. Microbiology Research Journal International. 2017; 20(2): 1-12.

12. Patil S.B and Magdum C.S. Phytochemical investigation and antitumor activity of Euphorbia hirta Linn. European Journal of Experimental Biology. 2011; 1(1): 51-56.

13. Uppal G, et al. Antidiabetic activity of ethanolic extract of Euphorbia hirta Linn. Der Pharmacia Lettre. 2012; 4(4): 1155-1161.

14. Tuhin RH, et al. Wound healing effect of Euphorbia hirta linn. (Euphorbiaceae) In alloxan-induced diabetic rats. BMC Complementary and Alternative Medicine. 2017; 17(423): 1-14.

15. Rathnakumar K, et al. Antiulcer Activity of Euphorbia hirta against Experimentally Induced Ulcer in Rats. Asian J. Pharm. Res. 2013; 3(3): 122-124.

16. Hilaire K.T, et al. Anti-Hemorrhoidal Activity of Leaf Extract of Adenia lobata (Jacq.) Engl. (Passifloraceae). Research J. Pharm. and Tech. 2012; 5(1): 63-67.

17. Devgun M, et al. Recent Techniques for Extraction of Natural Products. Research J. Pharm. and Tech. 2010; 3(3): 644-649.

18. Kumar P.A, and Saini B. HPLC Analysis and Isolation of Rutin from Stem Bark of Ginkgo biloba L. Journal of Pharmacognosy and Phytochemistry. 2013; 2(4): 68-71.

19. Tuchilus C, et al. Rutin semisynthetic derivatives with antifungal properties. Farmacia.  2017; 65(2): 184-188.

20. Rathnakumar K, et al. Effect of Euphorbia hirta in Napthalene Induced Cataract in Rats. Research J. Pharm. and Tech. 2013; 6(8): 1-3.

21. Karwani G, et al. Hepatoprotective activity of Chenopodium album Linn. in Ethanol induced Hepatotoxicity in Rats. Research J. Pharm. and Tech. 2015; 8(6):  669-673.

22. Chinedu E, et al. A New Method for Determining Acute Toxicity in Animal Models Toxicology International. 2013; 20(3): 224-226.

23. Darwin C. R, et al. Acute and sub-acute toxicological evaluation of aqueous and ethanol fractions of Annona squamosa root a traditional medicinal herb. Research J. Pharm. and Tech. 2011; 4(9): 1475-1479.

24. Cletus A.U, et al. Anti- hemorrhoid evaluation of selected medicinal plants used in Bali north-est Nigeria for the treatment of hemorrhoids. Journal of Pharmaceutical Research International. 2017; 18(3): 1-6.

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DOI: 10.5958/0974-360X 

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