ABSTRACT:
Background: Breast cancer is the second most common cancer in females. VEGF-C overexpression has been reported in breast cancer patients, and correlates with metastasis and poor prognosis. Objective: Determination the serum VEGF-C concentration in breast cancer patients, and its change after treatment. Methodology: This is a prospective, cross sectional study, include 65 women (30 with breast cancer, 35 healthy) met the study criteria. the serum VEGF-C values were measured at the beginning and after finishing the treatment. Results: there is no differences in age between two groups, The mean of serum VEGF-C values was higher in breast cancer patients (1122.74±853.97 U/L vs 334.55±522.6 U/L; P<0.00), . Serum VEGF-C level was significantly higher in breast cancer patients before the treatment compared with after treatment (P <0.01). Conclusion: Serum VEGF-C value has a good correlation with breast cancer.
Cite this article:
Amani Assaf, Jumana Al-Saleh. Evaluation the Serum vascular endothelial growth factor C (VEGF-C) value in breast cancer patients. Research J. Pharm. and Tech 2020; 13(9):4277-4279. doi: 10.5958/0974-360X.2020.00755.6
Cite(Electronic):
Amani Assaf, Jumana Al-Saleh. Evaluation the Serum vascular endothelial growth factor C (VEGF-C) value in breast cancer patients. Research J. Pharm. and Tech 2020; 13(9):4277-4279. doi: 10.5958/0974-360X.2020.00755.6 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2020-13-9-43
REFERENCES:
1. International Agency for Research on Cancer. GLOBOCAN 2012 (IARC) Section of Cancer Surveillance (8/2/2015) Cancer Incidence and Mortality Worldwide Lyon, France.
2. Ran S, Volk L, Hall K, et al. Lymphangiogenesis and lymphatic metastasis in breast cancer. Pathophysiology 2010;17(4): 229-251.
3. Ferrara N. Vascular endothelial growth factor: Basic science and clinical progress. Endocr Rev. 2004;25(4): 581-611.
4. Zhao YC, Ni XJ, Li Y, et al. Peritumoral lymphangiogenesis induced by vascular endothelial growth factor C and D promotes lymph node metastasis in breast cancer patients. World J Surg Oncol 2012; 10:165.
5. Liu XL, Huang Y, Chen P. Expression of hMAN, VEGF-C and VEGFR-3 in breast cancer tissues and its relation with prognosis. Acad J Sec Mil Med Uni 2013, 10; 1078-1082.
6. Bando H, Weich HA, Horiguchi S, et al. The association between vascular endothelial growth factor-C, its corresponding receptor, VEGFR-3, and prognosis in primary breast cancer: a study with 193 cases. Oncol Rep 2006, 15(3): 653-659.
7. Gisterek I, Matkowski R, Lacko A, et al. Serum vascular endothelial growth factors a, C and d in human breast tumors. Pathol Oncol Res 2010; 16(3):337-344.
8. Gu Y, Qi X, Guo S. Lymphangiogenesis induced by VEGF-C and VEGF-D promotes metastasis and a poor outcome in breast carcinoma: a retrospective study of 61 cases. Clin Exp Metastasis 2008, 25(7):717-725.
9. Lin Y, Liu F, Fan Y, et al. Both high expression of pyruvate kinase M2 and vascular endothelial growth factor C predicts poorer prognosis in human breast cancer. Int J Clin Exp Pathol 2015; 8(7): 8028-8037.
10. Zhang J, Zhang G, Yang S, et al. Macrophage migration inhibitory factor regulating the expression of VEGF-C through MAPK signal pathways in breast cancer MCF-7 cell. World J Surg Oncol, 2016; 14:51.
11. Zajkowska M, Lubowicka E, Fiedorowicz W, et al. Human Plasma Levels of VEGF-A, VEGF-C, VEGF-D, their Soluble Receptor - VEGFR-2 and Applicability of these Parameters as Tumor Markers in the Diagnostics of Breast Cancer. Pathol Oncol Res. 2019;25(4):1477-86
12. Thammineni KL, Thakur GK, Kaur N, et al. Significance of MMP-9 and VEGF-C expression in North Indian women with breast cancer diagnosis. Mol Cell Biochem. 2019;457(1-2):93-103.
13. Liang B, Li Y. Prognostic Significance of VEGF-C Expression in Patients with Breast Cancer: A Meta-Analysis. Iran J Public Health 2014, 43(2):128-135.
14. Zhang Z, Luo G, Tang H, et al. Prognostic Significance of High VEGF-C Expression for Patients with Breast Cancer: An Update Meta Analysis. PLoS ONE 2016, 11(11): e0165725.
15. Wang CA, Harrell JC, Iwanaga R, et al. Vascular endothelial growth factor C promotes breast cancer progression via a novel antioxidant mechanism that involves regulation of superoxide dismutase 3. Breast Cancer Res 2014, 16(5):462.