Author(s):
Rukhmakova O. A., Karpenko I. A., Yarnykh T. G.
Email(s):
rukhmakovaolga@gmail.com
DOI:
10.5958/0974-360X.2020.00765.9 
Address:
Rukhmakova O. A., Karpenko I. A., Yarnykh T. G.
National University of Pharmacy, Ukraine, 61168, Kharkov, Valentynovskaya str., 4.
*Corresponding Author
Published In:
Volume - 13,
Issue - 9,
Year - 2020
ABSTRACT:
Objectives: the development of definition methodic of the nasal gel’s “Phytorin-plus” active substances. Materials and Methods: the development of identification and quantitative definition methodic of licorice root dry extract in the experimental series of the nasal gel “Phytorin-plus” was carried out by HPLC method. To determine the glycyrrhizin acid (GA) was used the modification of the procedure described in the State Pharmacopoeia, validation was carried out only for proof of specificity. To confirm the presence of essential oils in the medicine, their identification and quantitative determination using the gas chromatography method were performed in accordance with the requirements of the State Pharmacopoeia. Results and Discussions: based on the conducted research we have developed identification and quantitative definition methodic of active substances of the nasal gel “Phytorin-plus”, description of which is given in the article. Conclusion: using the HPLC method, an identification was made and the content of GA in the medicine was determined. The content of GA was 13.03 mg per gram of the nasal gel. The methodic of identification and quantitative determination of essential oils of pine and eucalyptus in the nasal gel by the gas chromatography method was proposed. Their contents ranged from 8.5 mg to 11.5 mg and 17.0 mg to 23.0 mg respectively.
Cite this article:
Rukhmakova O. A., Karpenko I. A., Yarnykh T. G. The Development of Definition Methodic of The Nasal Gel’s “Phytorin-Plus” Active Substances. Research J. Pharm. and Tech 2020; 13(9):4329-4333. doi: 10.5958/0974-360X.2020.00765.9
Cite(Electronic):
Rukhmakova O. A., Karpenko I. A., Yarnykh T. G. The Development of Definition Methodic of The Nasal Gel’s “Phytorin-Plus” Active Substances. Research J. Pharm. and Tech 2020; 13(9):4329-4333. doi: 10.5958/0974-360X.2020.00765.9 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2020-13-9-53
REFERENCES:
1. Allergology and Immunology: National leadership; Moscow, GEOTAR-Media, 2009: 649.
2. Greiwe J., Bernstein J. A. Nonallergic rhinitis: diagnosis. Immunol. Allergy Clin. North Am. 2016; 36: 289-303.
3. Rondón C., Bogas G., Barrionuevo E. et al. Nonallergic rhinitis and lower airway disease. Allergy. 2017; 72: 24-34.
4. Smith D. F., Ishman S. L., Tunkel D. E. et al. Chronic rhinosinusitis in children: race and socioeconomic status. Otolaryngol. Head. Neck. Surg. 2013; 4 (149): P. 639-644.
5. Kilgore D., Najm W. Common respiratory diseases. Prim. Care. 2010; 37 (2): 297-324.
6. Shishkina A.V. Analysis of the domestic pharmaceutical market of soft medicinal forms. Pharmacy. 2013; 1: 28-30.
7. Medicinal products from plants (index): Textbook for students of Pharmacy Faculty; Irkutsk, IGMU, 2011: 74.
8. Rukhmakova O. A., Karpenko I. A., Yarnykh T. G. Experimental substantiation of the composition of the base of nasal gel for the treatment of viral rhinitis. Actual questions of pharmaceutical and medical science and practice. 2018; 3 (28): 276-280.
9. Karpenko I. A., Rukhmakova O. A., Yarnykh T. G. Experimental substantiation of the composition of nasal gel under the conditional name “Phytorin-plus”. Pharmaceutical journal. 2018; 1: 29-33.
10. Rukhmakova O. A., Karpenko I. A., Yarnykh T. G. Technological aspects of nasal gel production of antiviral action. Management, Economics and Quality Assurance in Pharmacy. 2019; 2 (58): 22-27.