Author(s):
Neha Rana, Vijender Singh, Mohd. Ali
Email(s):
nehaa_rana@yahoo.co.in , vijender.singh@sharda.ac.in , maliphyto@gmail.com
DOI:
10.5958/0974-360X.2020.00720.9 
Address:
Neha Rana1, Dr.Vijender Singh2, Dr.Mohd. Ali3
1Raj Kumar Goel Institute of Technology (Pharmacy), Ghaziabad, 201004.
2Sharda School of Pharmacy, Greater Noida, Uttar Pradesh, 201306.
3Jamia Hamdard, New Delhi, 110062.
*Corresponding Author
Published In:
Volume - 13,
Issue - 9,
Year - 2020
ABSTRACT:
Background: Rheumatoid arthritis is an inflammation of joints with increased cellularity of synovial tissue. It is characterized by pain, swelling and stiffness of synovial joints. Allopathic drugs like NSAID’S, Celecoxib and Duloxetine have been used with adverse effects. To overcome these side effects herbal use of medicines has increased due to increased safety and efficacy. Herbal medicines have side effects like low bioavailability and low lipophilicity. Emulgels are one of the formulations to overcome these drawbacks. Aim : The aim of present study is to formulate polyherbal emulgels and to characterize it by using various evaluation parameters. Method: Seven emulgels F-1, F-2, F-3, F-4, F-5, F-6 and F-7 were formulated according to the formula designed and were evaluated for characteristics of gels like physicochemical parameters, spreadability, extrudability and viscosity. Result and Conclusion: F-4 and F-7 was found to be optimized formulations comparative to other emulgels. Thus these emulgels can be further evaluated for in vitro and in vivo anti inflammatory and anti-arthritic activity respectively.
Cite this article:
Neha Rana, Vijender Singh, Mohd. Ali. Formulation and Characterization of Ginger oil loaded Polyherbal Emulgels having extracts of Nardostachys jatamansi, Andrographis paniculata and Celaestrus paniculatus. Research J. Pharm. and Tech 2020; 13(9):4077-4083. doi: 10.5958/0974-360X.2020.00720.9
Cite(Electronic):
Neha Rana, Vijender Singh, Mohd. Ali. Formulation and Characterization of Ginger oil loaded Polyherbal Emulgels having extracts of Nardostachys jatamansi, Andrographis paniculata and Celaestrus paniculatus. Research J. Pharm. and Tech 2020; 13(9):4077-4083. doi: 10.5958/0974-360X.2020.00720.9 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2020-13-9-8
REFERENCES:
1. Arora Neha, Rai-Pandey Shashi. GC-MS analysis of the essential oil of Celastrus paniculatus Wild. Seeds and antioxidant, anti-inflammatory study of its various solvent extracts. Industrial Crops and Products. 2014: 345-351.
2. Bagchi A, Oshima Y, Hinkino H. Neolignans and Lignans of Nardostachys jatamansi roots. Planta Med. 1991; 1:96-97.
3. Bhagat Madhulika, Pandita Moti Renu, Saxena Kumar Ajit. In vitro and In vivo Biological activities of Nardostachys jatamansi roots. Medicinal and Aromatic Plants. 2013;2(6):1-4
4. Bhanumathy.M. Chandrasekar S.B, Chandur Uma. Somasundaram.T. Phyto-pharmacology of Celastrus paniculatus: An Overview. International Journal of Pharmaceutical Sciences and Drug Research. 2010;2(3):176-181.
5. Sharma P.V. Samhita Chakra, Chankhambhia Orientatia Varanasi.1983;Vol-II:173.
6. Dehkordi-Ghassemi Nasrolah, Sajjadi Ebrahim, Koojani-Shafiei Hamed, Keshvari Mahtab, Hoseini Masih-Sayyed. Identification of Chemical compounds of Nardostachys jatamansi essence available in Iran. Journal of HerbMed Pharmacology. 2014;3(2):83-86.
7. Dixit Gouri, Misal Ganesh, Gulkari Vijay, Upadhye Kanchan. Formulation and Evaluation of Polyherbal gel for anti-inflammatory activity. International Journal of Pharmaceutical Sciences and Research. 2013;4(3):1186-1190.
8. Dua V.K, Ojha V.P, Biswas.S, Valecha.N, Singh.N, Sharma V.P. Antimalarial activity of different fractions isolated from the leaves of Andrographs paniculata. Journal of Medicinal and Aromatic Plant Sciences. 1999;21:1069-1073.
9. Gupta Richa, Gupta Das Ghanshyam. Formulation Development and Evaluation of anti-inflammatory potential of Cordia oblique Topical Gel on animal model. Pharmacogn J. 2017;9(6):S93-S98.
10. Handa S.S , Sharma J.D. Hepatoprotective activity of Andrographolide from Andrographis paniculata against Carbon Tetrachloride. Indian J Med Res. 1990; 92:276-283.
11. Jadhav Kisan .R, Kadam.J.Vilasrao. Stability enhancement and in vitro permeation of Erythromycin from Lecithin-IPM Organogel. Research Journal of Pharmcy and Technology. 2008;1(1):33-39.
12. Jain S.K, Tarafder C.R. Native plants remedies for snake-bite among adivasis of Central India. Indian Medical Journal. 1964;57:307-369.
13. Joshi.H, Parl. M. Nardostachys jatamansi improves learning and memory in mice. J.Med Food. 2006;9:113-118.
14. Kaur Preet Loveleen, Garg Rajeev, Gupta. GD. Topical Gels: A Review. Research Journal of Pharmacy and Technology. 2010;3(1):5-9.
15. Khan.I.A, Khanum Atiya. Role of Biotechnology in Medicinal and Aromatic Plants. Ukaaz Publications, Hyderabad. 2000;3:6.
16. Khullar Rachit, Kumar Deepinder, Seth Nimrata, Saini Seema. Formulation and evaluation of Mefenamic acid Emulgel for Topical Delivery. Saudi Pharmaceutical Journal. 2012;20:63-67.
17. Kulyal Poonam, Tiwari U K, Shukla A, Gaur A K. Chemical constituents isolated from Andrographis paniculata. Indian Journal of Chemistry. 2010; 49B:356-359.
18. Kumar R.A, Sridevi.K, Kumar N.V, Nandguri.S, Rajagopal.S. Anticancer and immunostimulatory compounds from Andrographis paniculata. J Ethnopharmacology. 2004;92:291-295.
19. Kumari.A, Singh Aniket, Saurabh.S.S, Rathore K.S, Issarani.R. Formulation and evaluation of Lycopene Emulgel. Indo American Journal of Pharmaceutical Sciences. 2015;2(6):1013-1027.
20. Kusuma.R, Rao Siva Samba.A. Formulation, Development and Evaluation of Indomethacin Emulgel using pregelatinized starch from Ipomoea batata tubers. Asian Journal of Pharmaceutics. 2015;9(4):S43-S50.
21. M. Radha.R, Sermakkani.M, Thangapandian.V. Evaluation of phytochemical and antimicrobial activity of Andrographis paniculata nees (Acanthaceae) aerial parts. International Journal of Pharmacy and Life Sciences. 2011;2(2):562-567.
22. Misso-Meye-Ngoua Leonid-Rick, Ndong Croix La De Jean, Obiang-Sima Cedric, Ondo Privat Joseph, Atome-Ndong Roger Guy, Abessolo Ovono Felix, engonga-Obame-Louis. Phytochemical studies, antiangiogenic, anti-inflammatory and antioxidant activities of Scyphocephalium ochocoa Warb. (Myristicaceae), medicinal plant from Gabon. Clinical Phytoscience. 2018;4(15):1-13.
23. Misso-Meye-Ngoua Leonid-Rick, Ndong Croix La De Jean, Obiang-Sima Cedric, Ondo Privat Joseph, Abessolo Ovono Felix, Engonga-Obame-Louis. Phytochemical screening, antioxidant, anti-inflammatory and antiangiogenic activities of Lophira procera A.chev.(Ochnaceae) medicinal plant from Gabon. Egyptian Journal of Basic and Applied Sciences. 2018; 5:80-86.
24. Musthafa Fairusa, C.Suja, B. Shuhaib. Formulation and Evaluation studies of Emulgel containing Mefenamic acid. European Journal of Pharmaceutical and Medical Research. 2018;6(1):376-387.
25. Nandkarni KM. In: The Indian Materia Medica. Popular Prakashan Private Limited, India. 1976: 840-842.
26. Navaneetha.K, Begum Asma, Sumalatha.P, Vinitha.D, Sravan.J, Chinnala Mohan Krishna. Formulation and in vitro evaluation of Capsaicin Emulgel for Topical delivery. Scholars Academic Journal of Pharmacy. 2017;6(6):281-287.
27. Pakhrare A.V, Deshmane S.V, Deshmane S.S, Biyani K.R. Design and Development of Emulgel preparation containing Diclofenac potassium. Asian Journal of Pharmaceutics. 2017;11(4):S712-S716.
28. Pande SD, Joshi SB, Kasture SB, Aurangabadkar VM. Effect of Some penetration enhancers on in vitro permeation of Glibemclamide. Research Journal of Pharmacy and Technology.2010;3(1):79-81.
29. Parimala Sudha, Shashidhar Gh., Sridevi. Ch, Jyothi.V, Suthakaran.R. Anti-inflammatory activity of Celastrus paniculatus seeds. International Journal of PharmTech Research. 2009;1(4):1326-1329.
30. Parveen Zahida, Siddique Saima, Muafia Shafique, Khan Jabeen Shaista, Khanum Razia. Volatile constituents, antibacterial and antioxidant activities of essential oil from Nardostachys jatamansi D.C. roots. Pharmacologyonline. 2011;3:329-337.
31. Puri.A, Saxena.R, Saxena R.P, Saxena K.C, Srivastava.V, Tondon J.S. Immunostimulant Agents from Andrographis paniculta. Journal Natural products. 1993;56(7):995-999.
32. Rahman Ur Aziz Rashid Mohammad, Zaid Ahmad Odazi, Mian Shariq Syed. Physiochemical analysis of Sumbul-al-Teeb (Nardostachys jatamansi D.C) rhizome along with its HPLC profile. Pharmacogn J. 2018;10(2):278-284.
33. Rajalakshmi.V, cathrine.L. Phytochemical screening and antimicrobial activity of ethanolic extract of Andrographis paniculata. Journal of Pharmacognosy and Phytochemistry. 2016;5(2):175-177.
34. Raut Sushil, Uplanchiwar Vaibhav. Comparative evaluation of Zidovudine loaded Hydrogels and Emulgels. Research Journal of Pharmacy and Technology. 2012;5(1):41-45.
35. Redkar.R.Mayuresh,Hasabe S Priyajit, Jadhav.T.Suraj. Review on Optimization base Emulgel formulation. Asian Journal of Pharmacy and Technology. 2019;9(3):228-2-37.
36. Saraswathi Beedha, Shabana SK. Formulation and Characterization of Tramadol Emulgel. Research Journal of Topical and Cosmetic Sciemces. 2017;8(2):53-60.
37. S.Eswaraiah, K.Swetha, M.Lohita. Emulgel:Review on Novel Approach to Topical Drug delivery. Asian Journal of Pharmaceutical Research. 2014;4(1):4-11.
38. Sharma.V.P, Sharma R.C. Bio-environmental Control of Malaria in Nadiad, Kheda District,Gujrat. Indian Journal of Malariology. 1986;23:95-117.
39. Shrikhande .V Pratiksha. Formulation and Evaluation of Polyherbal Topical anti-inflammatory Emulgel. Research Journal of Pharmacy and Technology. 2013;6(1):118-122.
40. Sreevani.P. Phytochemical and Pharmacological Activities of Andrographis paniculata Nees.a Review. International Journal of Science and Research. 2015;4(1):1887-1890.
41. Sundari Prasuna Pingali, Mullapudi Deepthi, Srinivas Prathima. Formulation and Evaluation of anti-arthritic Polyherbal Emulgel. International Journal of Pharmacy and Technology. 2014;6(2):6608-6621.
42. Thakur Susheel, Thakur Nisha, Ghosh Shekar Niladry. Formulation and in vitro evaluation of Polyherbal emulgel containing Tinospora cordifolia and Curcumin for treatment of Arthritis. International Journal of Pharmaceutical Sciences and Drug Research. 2016;8(5):259-264.
43. Udgirkar.B Dattatreya, Doddayya Hiremath. Studies on Topical gel formulations of Flurobiprofen containing different penetration enhancers. Research Journal of Topical and Cosmetic Sciences. 2010;1(1):33-36.
44. Uniyal M.R, R.K issar. Commercially and traditionally important medicinal plants of Mandakini valley of Uttarakhand Himalayas. J. ResIndian Med . 1969;4:83-96.
45. Y.Saikumar,V.Saikishore. Role of penetration enhancers in Transdermal drug delivery system. Research Journal of Pharmaceutical Dosage forms and Technology. 2012;4(6):300-308.