Author(s): Nazemoon Reddy, Swarnalatha Dugasani, Devanna Nayakanti


DOI: 10.5958/0974-360X.2021.00050.0   

Address: Nazemoon Reddy1, Swarnalatha Dugasani2, Devanna Nayakanti3
1Research Scholar, Research and Development, Jawaharlal Nehru Technological University, Ananthapuramu, AP, India.
2Principal and Professor, Department of Pharmacognosy, Annamacharya College of Pharmacy,Rajampeta, Kadapa, AP, India.
3Director, Jawaharlal Nehru Technological University - Oil Technological and Pharmaceutical Research Institute, Ananthapuramu, AP, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 1,     Year - 2021

This research aimed to prepare Telmisartan solid dispersions with polymer blend [Equal portion of PVP K-30, Poloxamer-188, and (HPMC) K4M. Various ratios of Telmisartan: Polymer blend in the ratios (1:1, 1:3, 1:5 and 1:7) were fabricated as solid dispersions by melting and solvent evaporation methods, later compressed into tablets. The solid dispersions were tested for physicochemical, and release constraints. The results discovered that the formulations were impressed with the increase in the solubility. Among them formulation with a 1: 5 ratio found to be the best proportion for enhancing the solubility and release rate of Telmisartan from the solid dispersions.

Cite this article:
Nazemoon Reddy, Swarnalatha Dugasani, Devanna Nayakanti. Solubility Promotion of Telmisartan by solid dispersions using Polymer combinations. Research J. Pharm. and Tech. 2021; 14(1):280-284. doi: 10.5958/0974-360X.2021.00050.0

Nazemoon Reddy, Swarnalatha Dugasani, Devanna Nayakanti. Solubility Promotion of Telmisartan by solid dispersions using Polymer combinations. Research J. Pharm. and Tech. 2021; 14(1):280-284. doi: 10.5958/0974-360X.2021.00050.0   Available on:

1.    Talluri MK, Kalyankar A, Ragampeta S. Synchronized separation of atorvastatin—an antihyperlipidemic drug with antihypertensive, antidiabetic, antithrombotic drugs by RP-LC for determination in combined formulations. Journal of Pharmaceutical Analysis. 2012 Aug 1; 2(4):285-92.
2.    Yang L, Shao Y, Han HK. Improved pH-dependent drug release and oral exposure of telmisartan, a poorly soluble drug through the formation of drug-aminoclay complex. International Journal of Pharmaceutics. 2014 Aug 25; 471(1-2):258-63.
3.    Leuner C, Dressman J. Improving drug solubility for oral delivery using solid dispersions. European journal of Pharmaceutics and Biopharmaceutics. 2000 Jul 3; 50(1):47-60.
4.    Bhise S, Mathure D, Patil MV, Patankar RD. Solubility enhancement of antihypertensive agent by solid dispersion technique. International Journal of Pharmacy & Life Sciences. 2011 Aug 1; 2(8).
5.    Zhong L, Zhu X, Luo X, Su W. Dissolution properties and physical characterization of telmisartan–chitosan solid dispersions prepared by mechanochemical activation. AAPS Pharm Sci Tech. 2013 Jun 1; 14(2):541-50.
6.    Park J, Cho W, Cha KH, Ahn J, Han K, Hwang SJ. Solubilization of the poorly water soluble drug, telmisartan, using supercritical anti-solvent (SAS) process. International Journal of Pharmaceutics. 2013 Jan 30; 441(1-2):50-5.
7.    Mahmah O, Tabbakh R, Kelly A, Paradkar A. A comparative study of the effect of spray drying and hot‐melt extrusion on the properties of amorphous solid dispersions containing felodipine. Journal of Pharmacy and Pharmacology. 2014 Feb; 66(2):275-84.
8.    Won DH, Kim MS, Lee S, Park JS, Hwang SJ. Improved physicochemical characteristics of felodipine solid dispersion particles by supercritical anti-solvent precipitation process. International Journal of Pharmaceutics. 2005 Sep 14; 301(1-2):199-208.
9.    Lieberman HA, Lachman L, editors. Pharmaceutical Dosage Forms: Tablets: 1980. Marcel Dekker; 1980.
10.    Kaur M, Bhatia RK, Pissurlenkar RR, Coutinho EC, Jain UK, Katare OP, Chandra R, Madan J. Telmisartan complex augments solubility, dissolution and drug delivery in prostate cancer cells. Carbohydrate Polymers. 2014 Jan 30; 101:614-22.
11.    Frączek J, Złobecki A, Zemanek J. Assessment of angle of repose of granular plant material using computer image analysis. Journal of Food Engineering. 2007 Nov 1; 83(1):17-22.
12.    Wong AC. Characterisation of the flowability of glass beads by bulk densities ratio. Chemical Engineering Science. 2000 Sep 15; 55(18):3855-9.
13.    Bergstrom CA, Norinder U, Luthman K, Artursson P. Molecular descriptors influencing melting point and their role in classification of solid drugs. Journal of Chemical Information and Computer Sciences. 2003 Jul 21; 43(4):1177-85.
14.    Juppo AM, Boissier C, Khoo C. Evaluation of solid dispersion particles prepared with SEDS. International Journal of Pharmaceutics. 2003 Jan 16; 250(2):385-401.
15.    Patel S, Sun CC. Macroindentation hardness measurement—modernization and applications. International Journal of Pharmaceutics. 2016 Jun 15; 506(1-2):262-7.
16.    Cruz J, Blanco M. Content uniformity studies in tablets by NIR-CI. Journal of Pharmaceutical and Biomedical Analysis. 2011 Sep 10; 56(2):408-12.
17.    Bushra R, Shoaib MH, Aslam N, Hashmat D, Rehman M. Formulation development and optimization of ibuprofen tablets by direct compression method. Pak. J. Pharm. Sci. 2008 Apr 1; 21(2):113-20.
18.    Pandey A, Sawarkar H, Singh M, Kashyap P, Ghosh P. UV spectrophotometric Method for estimation of Telmisartan in Bulk and Tablet Dosage form. International Journal of Chem Tech Research. 2011 Apr; 3(2):657-60.
19.    Chaudhari P, Meshram P, Chaskar P. Formulation and Evaluation of Fast Disintegrating Tablet of Telmisartan. Inventi Impact: Pharm Tech. 2013 Jul 15.
20.    Patel B, Parikh RH, Swarnkar D. Enhancement of dissolution of Ttelmisartan through use of solid dispersion technique-surface solid dispersion. Journal of Pharmacy & Bioallied Sciences. 2012 Mar; 4(Suppl 1): S64.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Recent Articles


Not Available