ABSTRACT:
Oral drug delivery system is one of the most widely used systems for treatment of various types of diseases. Conventional dosage forms like tablets, capsules have various disadvantages. They cannot be easily swallowed by young and elderly patients. They require water for swallowing which makes it difficult to suit patient choice during travelling. Another disadvantage of conventional dosage form is that their therapeutic response is slow and patient has to take tablets around two to three times a day to get proper relief. Nowadays in order to give rapid relief to patients mouth dissolving or fast orally disintegrating tablets are formulated. Mouth dissolving tablets are a type of tablets which disintegrates in mouth within seconds and they give rapid relief to patients within minutes without use of water. The main objective of present study was to develop, formulate and evaluate mouth dissolving tablet of nonsteroidal anti-inflammatory drug. Meloxicam basically belongs to COX-1 inhibitor. The drug Meloxicam is used to provide rapid relief from chronic pain by inhibiting production of prostaglandin hormone. The mouth dissolving tablet of Meloxicam was prepared by direct compression method with an aim to check fast disintegration of tablet by using different concentrations of super disintegrants. The formulated mouth dissolving tablets were evaluated for weight variation, friability, hardness, in vitro disintegration time, in vitro dissolution time etc. Different concentration of super disintegrants like sodium starch glycolate (SSG) and maltodextrin (MDx) were used to find out which tablets batch disintegrates fast and will provide quick patient relief.