Author(s):
Nikeherpianti Lolok, I. Sahidin, Adi Sumiwi, Ahmad Muhtadi
Email(s):
nikeherpianti.apt@gmail.com
DOI:
10.52711/0974-360X.2021.00883
Address:
Nikeherpianti Lolok1,2, I. Sahidin3, Sri Adi Sumiwi1, Ahmad Muhtadi1
1Faculty of Pharmacy, Universitas Padjadjaran, Indonesia.
2Faculty of Pharmacy, Mandala Waluya, Health Science Academy, Indonesia.
3Faculty of Pharmacy, Halu Oleo University, Indonesia.
*Corresponding Author
Published In:
Volume - 14,
Issue - 10,
Year - 2021
ABSTRACT:
Diabetes mellitus (DM) is a problem that deserves attention because of its increasing prevalence every year. The
prevalence of DM based on WHO in 2030 is predicted to reach 366 patients. Epidemiologically, it is estimated
that in 2030 the prevalence of DM in Indonesia reaches 21.3 million people. The purpose of this study was to
determine the effectiveness of glycosides from noni fruit on reducing blood sugar levels in normal rats induced
by diabetes by the method of glucose tolerance and induction of streptozotocin (STZ). Antidiabetic effect testing
was divided into 8 groups namely 4 groups for oral glucose tolerance test in male mice (positive control group,
negative control group, glycoside control group, and normal group), 4 other groups for testing with STZ
induction (positive control group, positive control group, negative control, glycoside control group, and normal
group). Oral glucose tolerance test results on normal mice showed that glycosides from noni fruit (Morinda
citrifolia L.) gave significantly different results with negative controls at minute 30 is 0.036 (p <0.05) and were
not significantly different from positive controls (0.462) subsequently at 120 minutes the results showed that the
glycoside group was significantly different from the negative group (0.028) and not significantly different from
the positive group (0.261). Tests with STZ induction method showed that the decrease in the level of blood sugar
induced by the glycoside group was not significantly different (p> 0.05) with the positive group on day 1
(0.056), day 3 (0.168), and day 7(0.141) so that it could be concluded that the glycosides from Noni fruit with a
dose of 150mg/kg body weight provides antidiabetic activity.
Cite this article:
Nikeherpianti Lolok, I. Sahidin, Adi Sumiwi, Ahmad Muhtadi. Antidiabetes effect of Noni Fruit (Morinda citrifolia L.) on mice with Oral Glucose Tolerance Method and Streptozotocin Induction Method. Research Journal of Pharmacy and Technology. 2021; 14(10):5067-1. doi: 10.52711/0974-360X.2021.00883
Cite(Electronic):
Nikeherpianti Lolok, I. Sahidin, Adi Sumiwi, Ahmad Muhtadi. Antidiabetes effect of Noni Fruit (Morinda citrifolia L.) on mice with Oral Glucose Tolerance Method and Streptozotocin Induction Method. Research Journal of Pharmacy and Technology. 2021; 14(10):5067-1. doi: 10.52711/0974-360X.2021.00883 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-10-1
REFERENCES:
1. World Health Organization. Global report on diabetes. 2016.
2. Vinayagam R, Xu B. Antidiabetic properties of dietary flavonoids: a cellular mechanism review. Nutrition & metabolism. 2015, 1; 12(1): 60
3. Sogandi, S. and Rabima, R., Identifikasi Senyawa Aktif Ekstrak Buah Mengkudu (Morinda citrifolia L.) dan Potensinya sebagai Antioksidan. Jurnal Kimia Sains dan Aplikasi, 2019. 22(5), pp.206-212.
4. Kwon O, Eck P, Chen S, Corpe CP, Lee JH, Kruhlak M, Levine
M. Inhibition of the intestinal glucose transporter GLUT2 by flavonoids. The FASEB Journal. 2007; 21(2): 366-77.
5. Arts IC, Hollman PC. Polyphenols and disease risk in epidemiologic studies. The American journal of clinical nutrition. 2005; 81(1): 317S-25S.
6. Coskun O, Kanter M, Korkmaz A, Oter S. Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and β-cell damage in rat pancreas. Pharmacological research. 2005 Feb 1; 51(2): 117-23.
7. Yashaswini S, Venugopal CK, Hegde RV, Mokashi AN. Noni: a new medicinal plant for the tropics. African journal of plant science. 2014; 8(5): 243-7.
8. Sornalakshmi V, Tresina Soris P, Paulpriya K, Packia Lincy M, Mohan VR. Oral glucose tolerance test (OGTT) in normal control and glucose induced hyperglycemic rats with Hedyotis leschenaultiana DC. Group. 2016; 1: 0-9..
9. Pawlus AD, Kinghorn AD. Review of the ethnobotany, chemistry, biological activity and safety of the botanical dietary supplement Morinda citrifolia (noni). Journal of Pharmacy and pharmacology. 2007; 59(12): 1587-609.
10. Lolok N, Mashar HM, Annah I, Saleh A, Yuliastri WO, Isrul M. Antidiabetic Effect of the Combination of Garlic Peel Extract (Allium sativum) and Onion Peel (Allium cepa) in Rats with Oral- Glucose Tolerance Method. Research Journal of Pharmacy and Technology. 2019; 12(5): 2153-6..
11. Abou Assi R, Darwis Y, Abdulbaqi IM, Vuanghao L, Laghari MH. Morinda citrifolia (Noni): A comprehensive review on its industrial uses, pharmacological activities, and clinical trials. Arabian Journal of Chemistry. 2017 July; 10(5): 691-707.