ABSTRACT:
Diabetes mellitus (DM) is a problem that deserves attention because of its increasing prevalence every year. The prevalence of DM based on WHO in 2030 is predicted to reach 366 patients. Epidemiologically, it is estimated that in 2030 the prevalence of DM in Indonesia reaches 21.3 million people. The purpose of this study was to determine the effectiveness of glycosides from noni fruit on reducing blood sugar levels in normal rats induced by diabetes by the method of glucose tolerance and induction of streptozotocin (STZ). Antidiabetic effect testing was divided into 8 groups namely 4 groups for oral glucose tolerance test in male mice (positive control group, negative control group, glycoside control group, and normal group), 4 other groups for testing with STZ induction (positive control group, positive control group, negative control, glycoside control group, and normal group). Oral glucose tolerance test results on normal mice showed that glycosides from noni fruit (Morinda citrifolia L.) gave significantly different results with negative controls at minute 30 is 0.036 (p <0.05) and were not significantly different from positive controls (0.462) subsequently at 120 minutes the results showed that the glycoside group was significantly different from the negative group (0.028) and not significantly different from the positive group (0.261). Tests with STZ induction method showed that the decrease in the level of blood sugar induced by the glycoside group was not significantly different (p> 0.05) with the positive group on day 1 (0.056), day 3 (0.168), and day 7(0.141) so that it could be concluded that the glycosides from Noni fruit with a dose of 150mg/kg body weight provides antidiabetic activity.