Author(s):
Sanjesh Rathi, Sohansinh Vaghela, Raj Shah, Shrenik Shah
Email(s):
rathi.sanjesh@gmail.com
DOI:
10.52711/0974-360X.2021.00935 
Address:
Sanjesh Rathi*, Sohansinh Vaghela, Raj Shah, Shrenik Shah
Department of Pharmaceutics, Saraswati Institute of Pharmaceutical Sciences and Research, Dhanap, Gujarat 382355.
*Corresponding Author
Published In:
Volume - 14,
Issue - 10,
Year - 2021
ABSTRACT:
The present research work done with an objective of preparation and evaluation of floating tablets of Febuxostat drug with Hydroxypropylenemethyl cellulose (HPMC), Polyox N-60K, Carbopol 934 P and Guar gum polymers. Floating tablets were based on effervescent approach using sodium bicarbonate a gas releasing agent. Direct compression method was used in present study for preparation of tablets. Effect of polymers was evaluated by studying drug release and floating time. In-vitro drug release profile indicates that sustained nature increased by increasing the concentration of polymer. The formulation containing Polyox N-60K and Carbopol 934 P in combination was optimized as it showed drug release up to 12hrs. Optimized formulation F18 was found stable during stability condition up to 1 month.
Cite this article:
Sanjesh Rathi, Sohansinh Vaghela, Raj Shah, Shrenik Shah. Formulation and Evaluation of Gastroretentive Floating Tablets of Febuxostat. Research Journal of Pharmacy and Technology 2021; 14(10):5359-5. doi: 10.52711/0974-360X.2021.00935
Cite(Electronic):
Sanjesh Rathi, Sohansinh Vaghela, Raj Shah, Shrenik Shah. Formulation and Evaluation of Gastroretentive Floating Tablets of Febuxostat. Research Journal of Pharmacy and Technology 2021; 14(10):5359-5. doi: 10.52711/0974-360X.2021.00935 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-10-53
REFERENCES:
1. Arora S, Ali J, Ahuja A, Khar R, Baboota S. “Floating drug delivery systems: a review.” AAPS Pharm. Sci. Tech, 2005, 06(03), 1-8.
2. Yeole P, Khan S, Patel V, “Floating drug delivery system: need and development.” Indian Journal of Pharmaceutical Science, 2005, 67(3), 265-71.
3. Talukder R, Fassihi R. “Gastroretentive delivery system: A mini review.” Drug Dev Ind Pharm, 2004, 30 (10), 1019-28.
4. Singh B, Kim K, “Floating drug delivery systems: An approach to oral controlled drug delivery via gastric retention.” J Con Rel,2000, 63, 235-59.
5. Rabiah B, Asmat M, Tabasum A, Saeema F, Nisar A, “Floating Oral In-Situ Gel: A Review”, Journal of Drug Delivery and Therapeutics, 2019, 9(2), 442-448.
6. Vyas S, Khar R, Gastroretentive systems In Controlled drug Delivery. Vallabh Prakashan, Delhi, India. 2006, 197-217.
7. Talukder R, Fissihi R. “Gastroretentive Delivery Systems: A Mini review”, Drug Dev. Ind. Pharm, 2004, 30, 1019-1028.
8. Parmar P, Pande S, Shah S, Sonara N. “Floating drug delivery system: A novel approach to prolong gastric retention.”World J Pharmacy Pharm Sci, 2014, 3(4), 418-444.
9. Gout disease Information, October 2019: -https://www.mayoclinic.org/diseases-conditions/ gout/symptoms-causes/syc-20372897.
10. Febuxostat Drug Information, October 2019: -https://pubchem.ncbi.nlm.nih.gov/compound/ Febuxostat.