Author(s): Sanjesh Rathi, Sohansinh Vaghela, Raj Shah, Shrenik Shah

Email(s): rathi.sanjesh@gmail.com

DOI: 10.52711/0974-360X.2021.00935   

Address: Sanjesh Rathi*, Sohansinh Vaghela, Raj Shah, Shrenik Shah
Department of Pharmaceutics, Saraswati Institute of Pharmaceutical Sciences and Research, Dhanap, Gujarat 382355.
*Corresponding Author

Published In:   Volume - 14,      Issue - 10,     Year - 2021


ABSTRACT:
The present research work done with an objective of preparation and evaluation of floating tablets of Febuxostat drug with Hydroxypropylenemethyl cellulose (HPMC), Polyox N-60K, Carbopol 934 P and Guar gum polymers. Floating tablets were based on effervescent approach using sodium bicarbonate a gas releasing agent. Direct compression method was used in present study for preparation of tablets. Effect of polymers was evaluated by studying drug release and floating time. In-vitro drug release profile indicates that sustained nature increased by increasing the concentration of polymer. The formulation containing Polyox N-60K and Carbopol 934 P in combination was optimized as it showed drug release up to 12hrs. Optimized formulation F18 was found stable during stability condition up to 1 month.


Cite this article:
Sanjesh Rathi, Sohansinh Vaghela, Raj Shah, Shrenik Shah. Formulation and Evaluation of Gastroretentive Floating Tablets of Febuxostat. Research Journal of Pharmacy and Technology 2021; 14(10):5359-5. doi: 10.52711/0974-360X.2021.00935

Cite(Electronic):
Sanjesh Rathi, Sohansinh Vaghela, Raj Shah, Shrenik Shah. Formulation and Evaluation of Gastroretentive Floating Tablets of Febuxostat. Research Journal of Pharmacy and Technology 2021; 14(10):5359-5. doi: 10.52711/0974-360X.2021.00935   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-10-53


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