Author(s): Hemant A. Deokule, Smita S. Pimple, Praveen D. Chaudhari, Ajit S. Kulkarni


DOI: 10.52711/0974-360X.2021.00962   

Address: Hemant A. Deokule1*, Smita S. Pimple1, Praveen D. Chaudhari1, Ajit S. Kulkarni2
1Department of Pharmaceutics, P.E.Society’s Modern College of Pharmacy, Nigdi – 411044, Dist-Pune Maharashtra, India.
2Gourishankar institute of Pharmaceutical Education and Research, Satara – 415015, Dist- Satara Maharashtra, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 10,     Year - 2021

Fast dissolving strips are used as novel approaches, as it dissolves rapidly in mouth and directly reaches the systemic circulation. In present research work, an attempt has been made to prepare mouth dissolving strips of Metoclopramide hydrochloride by using a novel film former Pullulan by solvent casting method. A33 full factorial design was utilized for the optimization of the effect of independent variables such as the amount of Pullulan, amount of PEF 400, amount of SSG on mechanical properties, and % drug release of strips. The drug compatibility studies using FTIR and DSC studies formulated strips were characterized for their physicochemical parameter like weight variation, visual appearance, folding endurance, thickness, disintegration time, drug content, and in vitro dissolution studies. FTIR and DSC studies revealed that the polymer is compatible with the drug. It was found that the optimum levels of the responses for a fast release strip could be obtained at low levels of Pullulan, PEG400, and SSG. The prepared strip was clear transparent and had a smooth surface. The surface pH was found 4.8 to 5.2 be in the range of to which is close to salivary pH, which indicates that strips may have less potential to irritate the oral mucosa, thereby they are comfortable. The drug release was found to be between 90.94 to 100.5% in 2 min. The in-vitro disintegration time of strips prepared with Pullulan was in the range of 19 to 57 sec. As the concentration of SSG increases the decrease in the disintegration time of strips a decrease. The dissolution rate increased with an increase in the concentration of SSG. Hence, it can be inferred that the fast dissolving oral strips of Metoclopramide hydrochloride may produce rapid action thereby improving bioavailability and enhance the absorption by avoiding the first-pass effect.

Cite this article:
Hemant A. Deokule, Smita S. Pimple, Praveen D. Chaudhari, Ajit S. Kulkarni. Fabrication and Evaluation of Mouth Dissolving Strips of Metoclopramide Hydrochloride by Using Novel Film Former. Research Journal of Pharmacy and Technology 2021; 14(10):5515-0. doi: 10.52711/0974-360X.2021.00962

Hemant A. Deokule, Smita S. Pimple, Praveen D. Chaudhari, Ajit S. Kulkarni. Fabrication and Evaluation of Mouth Dissolving Strips of Metoclopramide Hydrochloride by Using Novel Film Former. Research Journal of Pharmacy and Technology 2021; 14(10):5515-0. doi: 10.52711/0974-360X.2021.00962   Available on:

1.    M.J. Rathbone, J. Hadgraft. Absorption of drugs from the human oral cavity. Int. J. Pharm: 1991; 74: 9–24.
2.    Y. Rojanasakul, L.Y. Wang, M. Bhat, D.D. Glover, C.J. Malanga, J.K.H. Ma. The transport barrier of epithelia: a comparative study on membrane permeability and charge selectivity in the rabbit. Pharm. Res. 1992; 9: 1029–1034.
3.    A.H. Shojaei. Buccal mucosa as a route for systemic drug delivery: a review, J. Pharm. Pharm. Sci. 1998; 1: 15–30.
4.    W.R. Galey, H.K. Lonsdale, S. Nacht. The in vitro permeability of skin and buccal mucosa to selected drugs and tritiated water. J. Invest. Dermat  1976; 67: 713–717.
5.    L. Schenkels, T.L. Gururaja, M.J. Levine, in M.J. Rathbone (Ed.), Oral Mucosal Drug Delivery. Marcel Dekker, New York: 1996; 191–220.
6.    A. Crama, J. Breitkreutzb, S. Desset-Brèthesc, T. Nunnd, C. Tuleuf. Challenges of developing palatable oral pediatric formulations. Int J Pharm. 2009; 365: 1–3.
7.    A.T. Florence. Neglected diseases, neglected technologies, neglected patients? Int J Pharm. 2008; 350: 1–2.
8.    Committee for Medicinal Products for Human Use, European Medicines Agency EMEA, Reflection paper: formulation of choice for the pediatric population: 2006.
9.    Barnhart SD and Sloboda MS. Dissolvable strips. Drug Dev tech: 2007; 1: 34-35.
10.    Singh RS, Saini GK, and Kennedy JF. Pullulan: microbial source, production, and application. Carbohydrate polymer: 2008; 73: Page 515-531.
11.    Quick- dissolving strips – A novel approach to drug. Oral Strip Technology: 2003; 3.
12.    Mashru RC, Sutariya VB, Sankalia MG, and Parikh PP. Development and evaluation of fast dissolving strip of salbutamol sulphate. Drug Dev Ind Pharm. 2005; 25-34.
13.    S. Ganguly, S.K. Mandal, S.K. Patra. Selection of Suitable Physico-Chemical Conditions for Gluconic Acid, Production by a Mutant Aureobasidium Pullutants, SG 80. Asian J. Research Chem., January 2013; 6(1): 83-85.
14.    S. J. Daharwal, Vaminee Madhukar, Deepak Kumar Biswas, Astha Verma. Selection of Percentage of Polymer for Development of Floating Matrix Tablet of Metoclopramide Hydrochloride. Research J. Pharma. Dosage Forms and Tech. 2010; 2(5): 329-334.
15.    Vaseeha Banu T. S, Mohammad Sameer Ansari Mohamed Khaleel. Development and Evaluation of Metoclopramide Hydrochloride Floating Microsphres for Controlled Release. Res. J. Pharma. Dosage Forms and Tech. 2019; 11(3): 173-177.
16.    Girish Pai K, M. Sreenivasa Reddy. Formulation and Evaluation of Extended Release Ocular Inserts prepared from Synthetic and Natural Biodegradable – Biocompatible Polymers. Research J. Pharm. and Tech. 2014; 7(1): 48-51.
17.    Sonte Sushmitha Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthya. Formulation and Evaluation of Mucoadhesive Fast Melt-Away Wafers Using Selected Polymers. Research J. Pharma. And Tech. 2014; 7(2): 176-180.
18.    Rudra Shekhar Bose, Subin Santosh, Nishi Vasa, Samprita Das, Kirti Balodi, Suneetha V. Exopolysaccharide and Culture Analysis of Pullulan producing Fungus and prevention of Oxidation of Product. Research J. Pharma. And Tech. 2017; 10(9): 3035-3042.
19.    Muthana S. Mashkour, Mohammed K. Kahlol, Sami W. AL-Hasnawi. Colorimetric Determination of Metoclopramide Hydrochloride and Glutathione by using 1, 2 Naphthaquinolinc-4-Sulphonate Sodium Reagents. Research J. Pharm. and Tech 2018; 11(8): 3290-3294.
20.    Prashant S. Wake, M. D. Kshirsagar. Design and Characterization of Solid Lipid Nanoparticle -Based Transdermal Drug Delivery System. Asian J. Res. Pharm. Sci. 2017; 7(2): 87-91.
21.    Compatibility study In-vitro drug release Study of Solid Lipid Nanoparticle-Based Transdermal Drug Delivery System for Rasagiline Mesylate. Asian J. Res. Pharm. Sci. 2017; 7(2): 92-96.
22.    Pawar Jaydeep B, Saka Manoj S, Aloorkar N. H. Formulation and Evaluation of Buccoadhesive Tablets of Metoclopramide Hydrochloride. Research J. Pharma and Tech., May 2012; 5(5): 608-614.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Recent Articles


Not Available