Author(s): Kiran C. Mahajan, Smita S. Pimple, Hemant A. Deokule

Email(s): kirancmahajan@gmail.com

DOI: 10.52711/0974-360X.2021.01014   

Address: Kiran C. Mahajan1*, Dr. Smita S. Pimple2, Hemant A. Deokule3
Department of Pharmaceutics, Progressive Education Society’s Modern College of Pharmacy, Nigdi-411044, Dist.-Pune, Maharashtra, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 11,     Year - 2021


ABSTRACT:
The present study aims to develop and optimize a self-emulsifying drug delivery system for paediatric patients to improve the oral bioavailability of the anthelmintic drug, Praziquantel (PZQ) and to perform it’s in-vitro dissolution study. The solubility of PZQ was estimated in various vehicles to select proper component combination. Capmul MCM (oil), Cremophore RH40 (surfactant) and PEG400 (co-surfactant) were employed to construct pseudo-ternary phase diagrams. Eight formulations composed of Capmul MCM, at Smix ratios (1:1, 2:1 & 3:1) were selected. The optimized formulation F7 has a mean globule size 14.73 nm with a negative zeta potential -44.43 mV. The results indicated that PZQ loaded SEDDS, showed enhanced solubilization and nanosizing potential to improve the absorption of the drug.


Cite this article:
Kiran C. Mahajan, Smita S. Pimple, Hemant A. Deokule. Formulation and Optimization of Self Emulsifying Drug Delivery System For Effective Anthelmintic Therapy. Research Journal of Pharmacy and Technology. 2021; 14(11):5831-7. doi: 10.52711/0974-360X.2021.01014

Cite(Electronic):
Kiran C. Mahajan, Smita S. Pimple, Hemant A. Deokule. Formulation and Optimization of Self Emulsifying Drug Delivery System For Effective Anthelmintic Therapy. Research Journal of Pharmacy and Technology. 2021; 14(11):5831-7. doi: 10.52711/0974-360X.2021.01014   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-11-39


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