Author(s):
Shaum Shiyan, Zubaidah, Galih Pratiwi
Email(s):
galihpratiwi@stikes-aisyiyah-palembang.ac.id
DOI:
10.52711/0974-360X.2021.01020 
Address:
Shaum Shiyan1, Zubaidah2,3, Galih Pratiwi2,3*
1Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Sriwijaya, Indralaya (OI) Sumatera Selatan 30662, Indonesia.
2Department of Pharmacy, STIKES ‘Aisyiyah Palembang, Sumatera Selatan 30152, Indonesia.
3Biomaterials and Drug Delivery System (BiDDS) Research Group, STIKES ‘Aisyiyah Palembang, Sumatera Selatan 30152, Indonesia.
*Corresponding Author
Published In:
Volume - 14,
Issue - 11,
Year - 2021
ABSTRACT:
Catechins are isolated from tea leaves and shown to have pharmacological activities. However, the permeability and absorption capacity of the digestive tract is low, thus affecting the value of bioavailability. Self-nano emulsifying drug delivery system (SNEDDS) is formulated as a breakthrough in nano delivery to increase the value of bioavailability and stability in a model of natural compounds, namely catechins. This study applies chemometrics to the simplex centroid design (SCD) to analyze the catechin-SNEDDS pre-optimization design. The factors defined include oleic acid, croduret 50-SS, and propylene glycol. Evaluation parameters include emulsification time, percent transmittance (%T), freeze-thaw, and endurance test. The results showed a formula that met the requirements at the time of emulsification, stability, and %T. There were four clusters of results from the principal component analysis - cluster analysis (PCA-CA) in the SCD formula. The evaluation between responses in the SCD optimization design is indicated to have a positive correlation. Analysis using multivariate chemometric can describe the characteristics of each formula and the response based on the parameters used, which refers to the similarity, grouping, and correlation of each formula and response. The PCA-CA technique can group formulas from SCD in similar clusters and provide important information regarding response patterns or correlations.
Cite this article:
Shaum Shiyan, Zubaidah, Galih Pratiwi. Chemometric Approach to Assess Response Correlation and its Classification in simplex centroid design for Pre-Optimization stage of Catechin-SNEDDS. Research Journal of Pharmacy and Technology. 2021; 14(11):5863-0. doi: 10.52711/0974-360X.2021.01020
Cite(Electronic):
Shaum Shiyan, Zubaidah, Galih Pratiwi. Chemometric Approach to Assess Response Correlation and its Classification in simplex centroid design for Pre-Optimization stage of Catechin-SNEDDS. Research Journal of Pharmacy and Technology. 2021; 14(11):5863-0. doi: 10.52711/0974-360X.2021.01020 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-11-45
REFERENCES:
1. Shanshan W, Shanshan W, Songbai L. Integration of (+)-Catechin and β-sitosterol to Achieve Excellent Radical Scavenging Activity in Emulsions. Journal Food Chemistry. 2019; 272: 596-603.
2. Setyawan EI, Setyowati EP, Rohman A, Nugroho AK. Simultaneous Determination of Epigallocatechin Gallate, Catechin, and Caffeine from Green Tea Leaves (Camellia sinensis L) Extract by RP-HPLC. Research Journal Pharmcy and Technology. 2020; 13(3):1489-1494.
3. Shiyan S, Herlina, Bella AM. Antiobesity and antihypercholesterolemic effects of white tea (Camellia sinensis) infusion on high-fat diet induced obese rats. Pharmaciana. 2017; 7(2): 278-288.
4. Shiyan S, Fitrya, Arimia, Pratiwi G. Inhibitory of α-glucosidase and Molecular Docking of White Tea Polyphenol (Camillia sinensis): Comparison of Several Solvent Modifications and Chemometrics Approach. Rasayan Journal of Chemistry. 2020; 13(3); 1472-1477.
5. Hodges JK, Zhu J, Yu Z, Vodovotz Y, Brock G, Sasaki GY. Intestinal-level Anti-inflammatory Bioactivities of Catechin-rich Green Tea: Rationale, Design, and Methods of a Double-blind, Randomized, Placebo-controlled Cross Over Trial in Metabolic Syndrome and Healthy Adults. Contemporary Clinical Trials Communications. 2019; 17: 100495.
6. Ezzat HM, Elnaggar YSR, Abdallah OY. Improved Oral Bioavailability of The Anticancer Drug Catechin Using Chitosomes: Design, In-vitro Appraisal and In-vivo Studies. International Journal of Pharmaceutics. 2019; 565: 488-498.
7. Abd-Elhakeem E, Teaima MHM, Abdelbary GA, El Mahrouk GM. Bioavailability Enhanced Clopidogrel-loaded Solid SNEDDS: Development and In-vitro/In-vivo Characterization. Journal of Drug Delivery Science and Technology. 2019; 49: 603-614.
8. Kader NSA, Ansari N, Bharti R, Mandavi N, Sahu GK, Jha AK, Sharma H. Novel Approaches for Colloidal Drug Delivery System: Nanoemulsion. Research Journal of Pharmaceutical Dosage Forms and Technology. 2018; 10(4): 253-258.
9. Deore SK, Surawase RK, Maru A. Formulation and Evaluation of O/W Nanoemulsion of Ketoconazole. Research Journal of Pharmaceutical Dosage Forms and Technology. 2019; 11(4): 269-274.
10. Kim JS, Din FU, Lee SM, Kim DS, Choi YJ, Woo MR, Kim JO, Youn YS, Jin SG, Choi HG. Comparative Study Between High-pressure Homogenisation and Shirasu Porous Glass Membrane Technique in Sildenafil Base-loaded Solid SNEDDS: Effects on Physicochemical Properties and In Vivo Characteristics. International Journal of Pharmaceutics. 2020. https://doi.org/10.1016/j.ijpharm.2020.120039.
11. Kumar R, Kumar R, Khurana N, Singh SK, Khurana S, Verma S, Sharma N, Kapoor B, Vyas M, Khursheed M, Awasthi A, Kaur J, Corrie J. Enhanced Oral Bioavailability and Neuroprotective Effect of Fisetin Through its SNEDDS Against Rotenone-induced Parkinson’s Disease Rat Model. Food and Chemical Toxicology. 2020; 144: 111590.
12. Debnath S, Shashank C, Babu MN, Kumar SR. Formulation and Development of a Compression coated, matrix based, tablet of Verapamil HCl using design of experiments. Asian Journal of Pharmacy and Technology. 2017; 7(3): 117-126.
13. Joshi H, Shelat P, Dave D. Optimization and Characterization of Lipid Based Nano Emulsion of Prednisolone Acetate for Ophthalmic Drug Delivery. Research Journal Pharmcy and Technology. 2020; 13(9): 4139-4147.
14. Saxena S, Bawa S, Katare DP. Statistical and Continuous Manufacturing Approach by Design of Experiment (DoE) for a Robust Synthetic Process of a Sorafenib Analogue. Research Journal Pharmcy and Technology. 2020; 13(1): 1-8.
15. De Moraes Filho ML, Busanello M, Prudencio SH, Garcia S. Soymilk with Okara Flour Fermented by Lactobacillus Acidophilus: Simplex-Centroid Mixture Design Applied in The Elaboration of Probiotic Creamy Sauce and Storage Stability. LWT. 2018; 93: 339-345.
16. Hoang VD. Chemometrics-assisted Spectrophotometric Determination of Ciprofloxacin and Naphazoline in Eye Drops. Asian Journal of Research in Chemistry. 2014; 7(5): 461-465.
17. Gandhi SV, Sonawane PS. Chemometric–Assisted UV Spectrophotometric Method for Determination of Cefixime Trihydrate and Cloxacillin Sodium in Pharmaceutical Dosage Form. Asian Journal of Research in Chemistry. 2018; 11(4): 705-709.
18. Shiyan S, Arifin A, Amriani A, Herlina, Pratiwi G. Immunostimulatory Activity of Ethanol from Calotropis gigantea L. Flower in Rats againts Salmonella typhiumurium Infection. Research Journal Pharmcy and Technology. 2020; 13(11): 5244-5250.
19. Wadhwa J, Asthana A, Shilakari G, Chopra AK, Singh R. Development and Evaluation of Nanoemulsifying Preconcentrate of Curcumin for Colon Delivery. The Scientific World Journal. 2015; 1-13.
20. Kanwal T, Kawish M, Maharjan R, Ghaffar I, Ali HS, Imran M. Design and Development of Permeation Enhancer Containing Self-Nanoemulsifying Drug Delivery System (SNEDDS) for Ceftriaxone Sodium Improved Oral Pharmacokinetics. Journal of Molecular Liquids. 2019; 289: 111098.
21. Senapati PC, Sahoo SK, Sahu AN. Mixed Surfactant Based (SNEDDS) Self-Nano Emulsifying Drug Delivery System Presenting Efavirent for Enhancemenet of Oral Bioavailability. Biomedicine and Pharmacotherapy. 2016; 80: 42-51.
22. Gupta S, Chavhan S, Sawant KK. Self-nanoemulsifying Drug Delivery Systemfor Adefovir Dipivoxil : Design, Characterization, In vitro and Ex vivo Evaluation. Colloids and Surfaces A : Physicochemial and Engeneering Aspects. 2011;. 392: 145-155.
23. Syukri Y, Martien R, Lukitaningsih E, Nugroho AE. Novel Self-nano Emulsifying Drug Delivery System (SNEDDS) of Andrographolde Isolated from Andrographis paniculata Nees: Characterization, In-vitro/In-vivo Assessment. Drug Delivery Science and Technology. 2018; 18: 1773-2247.
24. Akiladevi D, Prakash H, Biju Gb, Madumitha N. Nano-novel approach: Self Nano Emulsifying Drug Delivery System (SNEDDS) - Review Article. Research Journal Pharmcy and Technology. 2020; 13(2): 983-990.
25. Kyatanwar AU, Jadhav KR, Kadam VJ. Self-micro emulsifying drug delivery system (SMEDDS): Review. Journal Pharmacy Research. 2010; 3(1): 75-83.
26. Hussaina A, Shakeelb F, Singha SK, Alsarrab IA, Farukc A, Alanazib FK, Christoper GVP. Solidified SNEDDS for The Oral Delivery of Rifampicin: Evaluation, Proof of Concept, In Vivo Kinetics, and In Silico GastroPlusTM Simulation. International Journal of Pharmaceutics. 2019; 566:2013-217.
27. Widyastuti I, Luthfah HZ, Hartono YI, Islamadina R, Can AT, Rohman A. Antioxidant Activity of Temulawak (Curcuma xanthorrhiza Roxb.) and its Classification with Chemometrics. Indonesian Journal of Chemometrics and Pharmaceutical Analysis, 2020; 1(1): 29.
28. Talekar SD, Haware RV, Dave RH. Evaluation of Self-Nanoemulsifying Drug Delivery System Using Multivariate Methods to Optimizing Permeability of Captopril Oral Film. European Journal of Pharmaceutical Sciences. 2019; 130: 215-224.
29. Khedekar K, Mittal S. Self Emulsifying Drug Delivery System: A Review. International Journal of Pharmaceutical Sciences and Research. 2013; 4(12): 4494-4507.
30. Villar AMS, Naveros BC, Campmany ACC, Trenchs MA, Rocabert CB, Bellowa LH. Design and Optimization of Self-nanoemulsifying Drug Delivery Systems (SNEDDS) for Enhanced Dissolution of Gemfibrozil. International Journal of Pharmaceutics. 2012; (431): 161-175.
31. Pouton CW, Porter CJH. Formulation of Lipid-based Delivery Systems for Oral Administration: Materials, Methods and Strategies. Advanced Drug Delivery Reviews. 2008; 60: 625–637.
32. Puspita OE, Suwaldi, Nugroho AK. Optimization of Self-nanoemulsifying Drug Delivery System for Pterostillbene. Journal Food Pharm Sci. 2016; 4:18-24.
33. Amrutkar C, Salunkhe K, Chaudhari S. Study on Self Nano Emulsifying Drug Delivery System of Poorly Water Soluble Drug Rosuvastatin Calcium. World Journal of Pharmaceutical Research. 2014; 3(4); 2137-2151.
34. Basalious EB, Shawky N, Badr-Eldin SM. 2010. SNEDDS containing bioenhancers for improvement of dissolution and oral absorption of lacidipine. I: development and optimization. International Journal of Pharmaceutics, 391: 203–211.
35. Marasini N, Yan YD, Poudel BK, Choi HG, Yong CS, Kim JO. Development and Optimization of Self-Nanoemulsifying Drug Delivery System with Enhanced Bioavailability by Box-Behnken Design and Desirability Function. Journal of Pharmaceutical Science. 2012; 101:12.
36. Indrati O, Martien R, Rohman A, Nugroho AK. Application of Simplex Lattice Design on the Optimization of Andrographolide Self Nanoemulsifying Drug Delivery System (SNEDDS). Indonesian Journal of Pharmacy. 2020; 31(2): 124-130.
37. Pratiwi G, Martien R, Murwanti R. Chitosan Nanoparticle as a Delivery System for Polyphenols from Meniran Extract (Phyllanthus Niruri L.): Formulation, Optimization, and Immunomodulatory Activity. International Journal of Applied Pharmaceutics. 2019; 11(2): 50-58.
38. Shiyan S, Hertiani T, Martien R, Nugroho AK. Optimization of a Novel Kinetic-Assisted Infundation for Rich-EGCG and Polyphenols of White Tea (Camellia Sinensis) Using Central Composite Design. International Journal of Applied Pharmaceutics. 2018; 10(6): 259-267.
39. Setyawan EI, Rohman A, Setyowati EP, Nugroho AK. Application of Factorial Design on the Extraction of Green Tea Leaves (Camellia sinensis L.). Journal of Applied Pharmaceutical Science. 2018; 8(04): 131-138.