Author(s):
Nadia Sadiq Majeed, Nada Ali Saleh, Radhiyah Abd AL-Baqi Aldujaili
Email(s):
nadia.albobaid@uokufa.edu.iq
DOI:
10.52711/0974-360X.2021.01047 
Address:
Nadia Sadiq Majeed1, Nada Ali Saleh2 , Radhiyah Abd AL-Baqi Aldujaili3
1Chemistry Department,Faculty of Education for girl, University of Kufa, Najaf.
2Pharmaceutical Department, Faculty of pharmacy,University of Kufa, Najaf.
3Chemistry Department,Faculty of Education for girl, University of Kufa, Najaf.
*Corresponding Author
Published In:
Volume - 14,
Issue - 11,
Year - 2021
ABSTRACT:
This paper involves synthesis new Mannich bases derived from Shiff' bases which prepared from isatin by the reaction of isatin with different aromatic amines to prepare Shiff bases derivatives (M, G, B, R, X, S), then Shiff's bases derivatives reacted with formaldehyde and piperazine to produce Mannich bases derivatives (M1, G1, B1, R1, X1, S1). The third step included the assay of biological activity of all compounds against four types of pathogens bacteria (Staphylococcus aureus, Granutice tella adiacens) gram positive and (E. coli, Proteus mirabilis) gram negative the results exhibited excellent biological activity for all derivatives compared to antibiotics (Ampicillin and Ciprofloxacin) these structures were identified by FT-IR,1HNMRand 13CNMR.
Cite this article:
Nadia Sadiq Majeed, Nada Ali Saleh, Radhiyah Abd AL-Baqi Aldujaili. Preparation,Characterization and Study of Biological Activity for some new derivatives Mannich's bases derived from Shiff's bases. Research Journal of Pharmacy and Technology. 2021; 14(11):6025-2. doi: 10.52711/0974-360X.2021.01047
Cite(Electronic):
Nadia Sadiq Majeed, Nada Ali Saleh, Radhiyah Abd AL-Baqi Aldujaili. Preparation,Characterization and Study of Biological Activity for some new derivatives Mannich's bases derived from Shiff's bases. Research Journal of Pharmacy and Technology. 2021; 14(11):6025-2. doi: 10.52711/0974-360X.2021.01047 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-11-73
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