Author(s): Marwan Talib Joudah, Shaker M. Saleh, Wisam Talib Joudah, Mohammed Talib Joudah

Email(s): mrwan_talib@yahoo.com , joudah@live.marshall.edu

DOI: 10.52711/0974-360X.2021.01085   

Address: Marwan Talib Joudah1, Shaker M. Saleh1, Wisam Talib Joudah2, Mohammed Talib Joudah3
1General Directorate of Education in Anbar, Gifted Guardianship Committee, Ministry of Education in Iraq.
2General Directorate of Vocational Education in Anbar. Ministry of Education in Iraq.
3Baghdad Teaching Hospital-Medical City/Ministry of Health in Iraq.
*Corresponding Author

Published In:   Volume - 14,      Issue - 12,     Year - 2021


ABSTRACT:
Renal failure is on the top list of kidney diseases as being frequently reported in many medical facilities around the globe. Human kidneys play an important role in excreting, reabsorbing, secreting and filtrating substances in the body. Healthy kidney must excrete the waste products of the body in urine and preserve albumin, and other useful substances in the body. The current study aims to figure out the expected factors of renal failure formation in dialysis patients. Likewise, it is designed to search for any correlation between the imbalanced levels of electrolytes and kidney deterioration. The current study was conducted in Ramadi city-Iraq with the assistance of Al-Ramadi Educational Hospital (REH). The (14th) samples of renal failure patients were collected from dialysis unit at (REH). (2-3 mL) of blood was taken from a patient’s vein. The serum was separated from plasma with the use of a centrifuge. All samples were undergone centrifuging for (4-7 min) at (550 rpm). Afterward, samples were subjected to biochemical examinations to determine the levels and quantities of some biochemical elements and other substances in the selected cases. It was found that some patients had been recorded with a decrease in glomerular filtration rate (GFR), high HbA1c level (? 6.5 mg/dL) (21.5%), anemia (? 12.0 mg/dL) (%100) in women and (? 13.5 mg/dL) in men (%100), Uremia (? 45mg/dL) (%100), hypercalcemia (?10.5 mg/dL) (%7.14), hyperkalemia (? 5.1 mg/dL) (%92.8), and Hypernatremia (?145 mg/dL) (%28.5). Some results obtained, imbalanced levels of the mentioned substances, are either progressed with kidney deterioration, or they are the causes of renal failure. Changes in the levels of some blood substances were observed, and positive results were obtained regarding the aim of the study. Levels or quantities of some blood substances play an important role in preserving kidneys good performance. For instance, when the level of glucose in blood raises, a severe damage to the blood vessels of the kidney takes place and results in poor kidney's performance. While, an increment in the K serum level causes a sudden cardiac death. Changing in some levels and quantities of blood substances could be a core cause of renal failure formation, however, some of them develops when kidney deteriorates.


Cite this article:
Marwan Talib Joudah, Shaker M. Saleh, Wisam Talib Joudah, Mohammed Talib Joudah. Biochemical Investigation to Determine the Factors Involved in Renal Failure Formation for Dialysis Patients. Research Journal of Pharmacy and Technology. 2021; 14(12):6275-0. doi: 10.52711/0974-360X.2021.01085

Cite(Electronic):
Marwan Talib Joudah, Shaker M. Saleh, Wisam Talib Joudah, Mohammed Talib Joudah. Biochemical Investigation to Determine the Factors Involved in Renal Failure Formation for Dialysis Patients. Research Journal of Pharmacy and Technology. 2021; 14(12):6275-0. doi: 10.52711/0974-360X.2021.01085   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-12-15


REFERENCES:
1.    Nicholas A. Boon; et al. Davidson’s, Principles and Practice of Medicine, Churchill Livingstone, India, 20th Edition.
2.    Sandiya Bindroo and J. Challa. Renal Failure. NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health. Jan 2018. p 1-7.
3.    What is Kidney Failure. National Institute of Diabetes and Digestive and Kidney Diseases NIDDK. [online]; U.S. Department of Health and Human Services, Posted May 31, 2020. https://www.niddk.nih.gov/health-information/kidney-disease/kidney-failure/what-is-kidney-failure.
4.    Kidney Disease. WebMD - Better information. Better health [online]; Posted May 31, 2020.https://www.webmd.com/a-to-z-guides/understanding-kidney-disease-basic-information#1
5.    Syed Safiullah Ghori, Mohammed Abdul Quddus, Hafsa Khalid. A Clinical Study of Acute Kidney Injury on using Antituberculosis Drugs in Geriatrics. Research J. Pharm. and Tech. 2017; 10(6): 1746-1750
6.    Suganya V, Jannathul Firdous, Karpagam T, Varalakshmi B, Shanmugapriya A, Gomathi S, Sugunabai J. Genotyping of Angiotensin Converting Enzyme (ACE 1) Gene in study subject with hypertension and Chronic Kidney Disease. Research J. Pharm. and Tech. 2017; 10(8): 2607-2610.
7.    Chertow GM; et al. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. Journal of American Society Nephrology. 2005 Nov;16(11):3365-70.
8.    Entedhar Rifaat Sarhat, Husamuldeen Salim Mohammed Saeed Siham A. Wadi. Altered Serum Markers of Omentin and Chemerinin Chronic Renal Failure Patients on Hemodialysis. Research J. Pharm. and Tech 2018; 11(4): 1667-1670.
9.    Subash Vijaya Kumar, M Sasi Kala, Satyendra Garg, Guru Sharan, Manoj K Deka. A Prospective Study of Aetiology, Pathogenesis, Management and Outcome of Acute Renal Failure. Research J. Pharm. and Tech 2010; 3(2): 327-332.
10.    Luo X, Jiang L, Du B, et al. A comparison of different diagnostic criteria of acute kidney injury in critically ill patients. Crit Care. 2014;18(4):R144. Published 2014 Jul 8.
11.    Mehta RL, Kellum JA, Shah SV. Acute Kidney Injury Network; Report of an initiative to improve outcomes in acute kidney Injury. Crit Care 2007; 11: R3.
12.    Duaa Dhia Hameed Al- Baghdadi, Rajha A.. Quality of Life for Hemodialysis Patients with Chronic Renal Failure. Research J. Pharm. and Tech 2018; 11(6): 2398-2403
13.    Eun-Mi Ham, Ji-Hye Lim, Sul-Hee Lee. The effect of Cool Dialysis on Pruritus and Fatigue in Hemodialysis Patients. Research J. Pharm. and Tech 2018; 11(5):1851-1854.
14.    Christina Pothen, Bibin Baby, Anusree Ashokan, Chinju Chacko, Pradeep Shenoy, Nandakumar UP. Drug Usage Pattern in Chronic Kidney Disease patients undergoing maintenance Hemodialysis. Research J. Pharm. and Tech. 2019; 12(10):5024-5028.
15.    Aziz H. Jasim, Narjis Hadi Al-Saadi. Biochemical Markers of Bone Turnover in Pre-dialysis, Chronic Renal Failure Patients. Research J. Pharm. and Tech 2019; 12(10):4909-4912.
16.    Ahmed, S., Khan, M. A., and Laila, T. Treatment and Prevention of Common Complications of Chronic Kidney Disease. Journal of Enam Medical College 2014; 4(1): 45-55.
17.    Vander et al.  Human Physiology: The Mechanism of Body (chapter 6: The Kidneys and Regulation of Water and Inorganic Ions), The McGraw−Hill Companies. (8th edition).
18.    Biosystems, Reagents and Instruments for Clinical and Agri-food Diagnostics. Biosystems. [online]. https://www.biosystems.es. [Accessed 31 May 2020].
19.    Heshmatollah Shahbazian1, Isa Rezaii. Diabetic kidney disease; review of the current knowledge. Journal of Renal Injury Prevention. 2013; 2(2): 73-80.
20.    Diabetic Kidney Disease. National Institute of Diabetes and Digestive and Kidney Diseases NIDDK. [online]; U.S. Department of Health and Human Services, https://www.niddk.nih.gov/health-information/diabetes/overview/preventing problems/diab etic-kidney-disease
21.    Senthilkumar S, Dhivya K. Prognostic Potential of Serum Biomarkers as Predictors for Cardiovascular Complications and Disease Progression in Chronic Kidney Disease Patients. Research J. Pharm. and Tech. 2016; 9(3): 227-234.
22.    Michael R. Zemaitis; Lisa A. Foris; Shruti Chandra; Khalid Bashir. Uremia. StatPearls. 2020, P. 1-18.
23.    Chris Higgins. Urea and creatinine concentration, the urea:creatinine ratio. Acute xare testing .org, Your scientific knowledge site. Oct 2016, p1-8.
24.    Lucia Del Vecchio and Francesco Locatelli. Anemia in chronic kidney disease patients: treatment recommendations and emerging therapies.  Expert Review of Hematology 2014; 7(4): 495–506.
25.    Ghassan F. Mohammmed, Safaa M. Sultan, Yaman Q. Sadullah. The relationship between Creatinine and patients with Renal Failure associated with anemia. Research J. Pharm. and Tech. 2020; 13(4):1633-1635.
26.    K. Sai Girisha, Mohan Ram. A Prospective Study on Efficacy of Mircera for Treating Anemia Associated with Chronic Kidney Disease. Research J. Pharm. and Tech 2017; 10(11): 3807-3809.
27.    Anemia in Chronic Kidney Disease. National Institute of Diabetes and Digestive and Kidney Diseases. NIDDK. [online]; U.S. Department of Health and Human Services, (Accessed June 4, 2020). https://www.niddk.nih.gov/health-information/kidney-disease/anemia.  
28.    Stojceva-Taneva O, Taneva B, Selim G. Hypercalcemia as a Cause of Kidney Failure: Case Report. Open Access Maced J Med Sci. 2016 Jun 15; 4(2):283-286.
29.    Patrick H. Pun, et al. Serum Potassium Levels and Risk of Sudden Cardiac Death Among Patients with Chronic Kidney Disease and Significant Coronary Artery Disease. CLINICAL RESEARCH, Kidney International Reports (2017) 2, 1122–1131
30.    Julie A. Wright* and Kerri L. Cavanaugh. Dietary Sodium in Chronic Kidney Disease: A Comprehensive Approach. NIH-PA Author Manuscript. Semin Dial. 2010 ; 23(4): 415–421.
31.    Kovesdy CP. Significance of hypo- and hypernatremia in chronic kidney disease. Nephrol Dial Transplant. 2012; 27(3):891‐898.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available