Author(s): Adel Alhabbal, Sameh Saber, Imad AbouKhamis

Email(s): sampharm81@gmail.com , sameh.mohamed@deltauniv.edu.eg

DOI: 10.52711/0974-360X.2021.01130   

Address: Adel Alhabbal1, Sameh Saber2*, Imad AbouKhamis1
1Department of Microbiology and Biochemistry, Faculty of Pharmacy, University of Damascus, Damascus, Syria.
2Department of Pharmacology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt.
*Corresponding Author

Published In:   Volume - 14,      Issue - 12,     Year - 2021


ABSTRACT:
Celiac disease (CD) is a disorder caused by an aberrant autoimmune response to gluten ingestion in genetically susceptible individuals. Its prevalence nears 1%, and it is not considered typical in the Middle East because of the lack of reports in the Arabic countries. Therefore, this study aimed to define the prevalence of celiac disease in the Syrian community. Healthy young adults and volunteers ranging between 5–65-year-old were tested from December 2018 till May 2019. Samples from the participant's sera were tested for anti-tissue transglutaminase antibody (tTG) IgA/IgG by ELISA using the human recombinant transglutaminase antigen. One hundred participants with a mean ± SD of 22 ± 14 years-old were recruited in the study. Only one participant was suspected of having celiac disease. The mean ± SD of anti-tTG IgA/IgG values were 9.81 ± 9.61 for IgA and 6.64 ± 6.60 for IgG. The study shows no significant difference in IgA or IgG titers between males and females at P = 0.7, P = 0.8, respectively. The estimation of seroprevalence of CD antibodies in a healthy Syrian population is close to 1%. We suggest that the underdiagnosed CD might pose a high risk in Syria, contrary to previous thoughts.


Cite this article:
Adel Alhabbal, Sameh Saber, Imad AbouKhamis. The hidden danger in Syria: Silent Celiac Disease. Research Journal of Pharmacy and Technology. 2021; 14(12):6536-0. doi: 10.52711/0974-360X.2021.01130

Cite(Electronic):
Adel Alhabbal, Sameh Saber, Imad AbouKhamis. The hidden danger in Syria: Silent Celiac Disease. Research Journal of Pharmacy and Technology. 2021; 14(12):6536-0. doi: 10.52711/0974-360X.2021.01130   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-12-60


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