Author(s): Vijayalaxmi B M, Damodara Gowda K M, Harshini Ullal

Email(s): dr_damodar@nitte.edu.in

DOI: 10.52711/0974-360X.2021.01154   

Address: Vijayalaxmi B M1, Damodara Gowda K M1*, Harshini Ullal2
1Dept of Physiology, K.S. Hegde Medical Academy, Nitte (Deemed to be University), Mangalore, Karnataka, India.
2Dept of Biotechnology, N.M.A.M. Institute of Technology, Karkala, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 12,     Year - 2021


ABSTRACT:
Background: The `fetal origins' hypothesis proposes that alterations in fetal nutrition result in a permanent change in physiology and metabolism, thereby predisposing to metabolic disorders in adult life. Turmeric (Curcuma longa L.), the wonder queen of Indian spice and a nutraceutical was extensively used in Ayurveda, Unani, and Siddha for various diseases. Having multiple benefits of Curcumin, we hypothesized that, rats suffered undernutrition during their perinatal period would develop metabolic disorders in their adult life, which would be effectively modulated by Curcumin. Therefore, the present study was designed to investigate the effect of Curcumin supplementation during perinatal life. Methods: It is an experimental study conducted using a rat model. The animals were divided into six groups. The insulin level was estimated by the enzyme-linked immunosorbent assay (ELISA) method. Plasma glucose and lipid profile by autoanalyzer method. HOMA-IR and AI were calculated. The difference was compared between the groups and within the group was done by one-way ANOVA. The p < 0.05 was considered as the level of significance. Results: The Bodyweight mean Triglyceride, Total cholesterol, LDL-C, Glucose, AI, and HOMA-IR was significantly increased (p=0.0001) in the Perun group, whereas HDL-C and Insulin were significantly decreased (p=0.001) as compared to control animals, which was effectively modulated by Curcumin in the animals of PeriCur group. Conclusion: The present study showed that perinatal undernutrition caused metabolic disorders in adult life and was effectively modulated by Curcumin supplementation during the perinatal period.


Cite this article:
Vijayalaxmi B M, Damodara Gowda K M, Harshini Ullal. Nutritional Enrichment with Curcumin during Perinatal period Alleviates Metabolic Disorders in The Adult Life. Research Journal of Pharmacy and Technology. 2021; 14(12):6681-6. doi: 10.52711/0974-360X.2021.01154

Cite(Electronic):
Vijayalaxmi B M, Damodara Gowda K M, Harshini Ullal. Nutritional Enrichment with Curcumin during Perinatal period Alleviates Metabolic Disorders in The Adult Life. Research Journal of Pharmacy and Technology. 2021; 14(12):6681-6. doi: 10.52711/0974-360X.2021.01154   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-12-84


REFERENCES:
1.    Kelly T, Yang W, Chen CS, Reynolds K, He J. Global burden of obesity in 2005 and projections to 2030. Int J Obes (Lond) 2008; 32:1431-7.  DOI: 10.1038/ijo.2008.102
2.     MD Wandhare, UA Deokate, SS Khadabadi, SP Hadke, HA Sawarkar. Comparative Estimation of Curcumin Content from Marketed Herbal Anti Rheumatic Tablets Formulation. Asian J. Research Chem. 2(3): July-Sept., 2009, page 340-343. https://ajrconline.org/AbstractView.aspx?PID=2009-2-3-30
3.     P. Venugopalan, T. V. Deepthi. Chemical and Pharmacological Studies on Curcuminoids. Asian J. Research Chem. 7(3): March 2014; Page 355-365. https://ajrconline.org/AbstractView.aspx?PID=2014-7-3-22
4.     Kiani A, Nielsen MO. Metabolic Programming: Origin of Non-Communicable Diseases in Early Life Nutrition. Int J Endocrinol Metab. 2011;9(3): 409-15. DOI: 10.5812/Kowsar.1726913X.3366
5.     Gowda KMD, Kumari NS, Ullal H. Role of Astaxanthin in the Modulation of Brain-Derived Neurotrophic Factor and Spatial Learning Behaviour in Perinatally Undernourished Wistar Rats. Nutritional Neuroscience. 2020 Jun;23(6):422–31.  doi: 10.1080/1028415X.2018.1515301.
6.     Lawlor DA, Davey Smith G, Clark H, Leon DA. The associations of birthweight, gestational age and childhood BMI with type 2 diabetes: findings from the Aberdeen Children of the 1950s cohort. Diabetologia. 2006;49(11):2614-7. DOI: 10.1007/s00125-006-0408-z
7.     McCance DR, Pettitt DJ, Hanson RL, Jacobsson LT, Knowler WC, Bennett PH. Birth weight and non-insulin dependent diabetes: thrifty genotype, thrifty phenotype, or surviving small baby genotype? BMJ. 1994;308(6934):942-5. DOI: 10.1136/bmj.308.6934.942
8.     Mukund Nagarnaik, Arun Sarjoshi, Ajay Bodkhe, Bhupendra Khanal, Mayuri Pise, Girish Pandya. Characterization of active constituents in Turmeric powder and validation of method for curcumin in samples. Asian J. Research Chem. 8(10): October 2015; Page 643-647. doi: 10.5958/0974-4150.2015.00102.9
9.     Amol A. Kadam, Amit P. Pratap. Study of the effect of Sodium dodecyl sulphate (SDS) on isolation of Curcumin from oleoresin of Turmeric (Curcuma longa). Asian J. Research Chem. 2018; 11(4):713-716. doi: 10.5958/0974-4150.2018.00126.8
10.    Keith M Godfrey, David JP Barker. Foetal programming and adult health. Public Health Nutrition 2001; 4(2B): 611-24. DOI: 10.1079/phn2001145
11.     Eriksson J, Forsén T, Tuomilehto J, Osmond C, Barker D. Size at Birth, Fat-Free Mass and Resting Metabolic Rate in Adult Life. Horm Metab Res. 2002;34(02):72-6. DOI: 10.1055/s-2002-20518
12.     Shailaja M, Gowda KD, Vishakh K, Kumari NS. Anti-aging role of curcumin by modulating the inflammatory markers in albino wistar rats. Journal of the National Medical Association. 2017 Mar 1;109(1):9-13. DOI: 10.1016/j.jnma.2017.01.005
13.     Lucas A. Role of nutritional programming in determining adult morbidity. Arch Dis. Child 1994; 71: 288-90. DOI: 10.1136/adc.71.4.288
14.     Sabale Prafulla, Potey Lata, Rahangdale Priya, Sabale Vidya. Novel Curcumin Derivatives: Targeted for Anti-Inflammatory Activity. Asian J. Research Chem. 2019; 12(2):49-54. doi: 10.5958/0974-4150.2019.00011.7
15.    Morgane PJ, Austin-LaFrance R, Bronzino J, Tonkiss J, Díaz-Cintra S, Cintra L, Kemper T, Galler JR. Prenatal malnutrition and development of the brain. Neurosci Biobehav Rev. 1993 Spring;17(1): 91-128. DOI: 10.1016/s0149-7634(05)80234-9
16.     Bindiya S, Gowda KD, Ashwini K, Roshima PM. Comparison of fat percentage with muscle strength/endurance and blood pressure response in young adults. National Journal of Physiology, Pharmacy and Pharmacology. 2017;7(10):1070–3. DOI: 10.5455/njppp.2017.7.0413916052017
17.     Sikora E, Scapagnini G, Barbagallo M. Curcumin, inflammation, ageing and age-related diseases. Immunity & Ageing. 2010 Dec;7(1):1. DOI: 10.1186/1742-4933-7-1
18.     Ravelli AC, van der Meulen JH, Michels RP, Osmond C, Barker DJ, Hales CN. Glucose tolerance in adults after prenatal expo- sure to famine. Lancet. 1998;351(9097):173-7. DOI: 10.1016/s0140-6736(97)07244-9
19. Kishu Tripathi. Curcumin-The Spice of Life-I. Research J. Pharmacognosy and Phytochemistry 2009; 1(3): 153-161. https://rjpponline.org/AbstractView.aspx?PID=2009-1-2-1
20.     Hitha H, Gowda D, Mirajkar A. Serum ferritin level as an early indicator of metabolic dysregulation in young obese adults - a cross-sectional study. Can J Physiol Pharmacol. 2018 Dec;96(12):1255–60. doi: 10.1139/cjpp-2018-0433
21.     Prafulla Sabale, Arjun Modi, Vidya Sabale. Curcuma longa Linn. A Phytochemical and Phytopharmacological Review. Research J. Pharmacognosy and Phytochemistry 2013; 5(2): 59-68.
22.     Satish B, Gowda DKM. Fast Food Consumption Pattern and Risk of Development of Obesity Among Young Individuals: A Population Based Study. International Journal of Food, Nutrition & Dietetics. 2018 Apr;6(1):5–12. DOI: http://dx.doi.org/10.21088/ijfnd.2322.0775.6118.1
23.     Lithell HO, McKeigue PM, Berglund L, Mohsen R, Lithell UB, Leon DA. Relation of size at birth to non-insulin dependent diabetes and insulin concentrations in men aged 50-60 years. BMJ. 1996;312(7028):406-10. DOI: 10.1136/bmj.312.7028.406
24.    Rahul Shivarkar, Satish Bhise, V Rama Mohan Gupta. Antituberculor activity of Curcuminoids isolated from Curcuma longa Rhizomes. Res. J. Pharmacognosy and Phytochem. 2021; 13(1):5-10. DOI: 10.5958/0975-4385.2021.00002.9
25.     Lawlor DA, Ronalds G, Clark H, Davey Smith G, Leon DA. Birth weight is inversely associated with incident coronary heart disease and stroke among individuals born in the 1950s. Circulation. 2005;112(10):1414-8. DOI: 10.1161/CIRCULATIONAHA.104.528356
26.    Kumari S, Somayaji TY, Tejashvi R, Gowda D, Rao C. Antioxidant, Erythrocyte Membrane Stabilization and Thrombolytic Potential of Carica Papaya (linn.). International Journal of Current Research. 2014 May;6(5):6474–80. DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(10).4478-83
27. Huxley RR, Shiell AW, Law CM. The role of size at birth and postnatal catch-up growth in determining systolic blood pressure: a systematic review of the literature. J Hypertens. 2000;18(7):815-31. DOI: 10.1097/00004872-200018070-00002
28. Sri Vasavi Reddy A, J. Suresh, Hemant K.S. Yadav, Apurva Singh. A Review on Curcuma longa. Research J. Pharm. and Tech. 5(2): Feb. 2012; Page 158-165. https://rjptonline.org/AbstractView.aspx?PID=2012-5-2-23
29. Eriksson J, Forsén T, Tuomilehto J, Osmond C, Barker D. Size at Birth, Fat-Free Mass and Resting Metabolic Rate in Adult Life. Horm Metab Res. 2002;34(02):72-6. DOI: 10.1055/s-2002-20518
30. Gowda DKM, Shetty L, Krishna AP, Kumari SN, Sanjeev G, Naveen P. The Efficacy of Nardostachys Jatamansi Against the Radiation Induced Hematological Damage In Rats. JCDR. 2013 Jun;7(6):982–6.  doi: 10.7860/JCDR/2013/5475.3078
31. Gonzalez-Barranco, J.; Rios-Torres, J.M.; Castillo-Martinez, L.; Lopez-Alvarenga, J.C.; Guilar-Salinas, C.A.; Bouchard, C.; Depres, J.P.; Tremblay, A. Effect of malnutrition during the first year of life on adult plasma insulin and glucose tolerance. Metabolism 2003, 52, 1005-1011. DOI: 10.1016/s0026-0495(03)00151-3
32. Swetha G., Sangeetha B., Prabhu S. A Review on Curcumin Nanoparticles and Its Controlled Delivery to Treat Degenerative Diseases. Asian J. Pharm. Tech. 2013; Vol. 3: Issue 4, Pg 218-222.
33. Vaisakh M. N., Anima Pandey. Assessment of curcumin release with different permeation enhancers. Research J. Pharm. and Tech. 5(3): March 2012; Page 408-410. https://rjptonline.org/AbstractView.aspx?PID=2012-5-3-16

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